基于芳基重氮盐的芳基自由基介导的不饱和键环化反应研究进展  

Recent Progress in Aryl Radical-Mediated Cyclization of Unsaturated Bonds Based on Aryldiazonium Salts

作　　者：姜松 南宁 何景昊 郭嘉程 秦景灏 谢叶香 欧阳旋慧 宋仁杰 Jiang Song;Nan Ning;He Jinghao;Guo Jiacheng;Qin Jinghao;Xie Yexiang;Ouyang Xuanhui;Song Renjie(Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle,Nanchang 330063;State Key Laboratory of Chemo/Biosensing and Chemometrics,Changsha 410082;Key Laboratory for Microstructural Control of Metallic Materials of Jiangxi Province,Nanchang 330063)

机构地区：[1]江西省持久性污染物控制与资源循环利用重点实验室,南昌330063 [2]化学生物传感与计量学国家重点实验室,长沙410082 [3]江西省金属材料微结构调控重点实验室,南昌330063

出　　处：《有机化学》2022年第12期3959-3978,共20页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.51878326,21861027,22161030,21901100);江西省自然科学基金(Nos.20212ACB203007,20204BCJ23010,20202ACBL216017,20212AEI91002,20202ACB203002);国家重点实验室专项课题经费(No.SKLCBSC-2021019)资助项目。

摘　　要：芳基重氮盐以其较高的反应活性和广泛的来源,被广泛应用于有机合成中.芳基重氮盐作为一种常见的亲电试剂通过保留N_(2)骨架和离去N_(2),在材料化学、染料化学和药物化学等领域有着非常广泛的应用.近些年,随着自由基化学的迅速发展,利用芳基重氮盐产生芳基自由基参与的环化反应也得到了迅速的发展.整理了近十年来关于芳基重氮盐产生芳基自由基参与的环化反应的文献,从芳基自由基对不饱和碳碳键、碳氮键的加成后构建各种环状化合物进行归纳.最后,对目前的研究进展进行了总结.Aryldiazonium salts are widely used in organic synthesis due to their high reactivity and readily availability.As a common arylation reagent,aryl diazonium salts have been widely used in material chemistry,dye chemistry and medicinal chemistry by retaining and leaving N_(2)skeleton.In recent years,with the rapid development of radical chemistry,the cyclization reaction involving aryl radicals,which produced by aryldiazonium salts,has also been developed rapidly,and this strategy also stimulates the enthusiasm of organic chemists to construct various ring compounds.In this review,the addition of unsaturated carbon-carbon bonds and carbon-nitrogen bonds to construct various cyclic compounds from aryl radicals is summarized and classified according to the size of the cyclic compounds.Finally,the current research progress is summarized.

关 键 词：芳基重氮盐 芳基自由基 不饱和键 环化反应 

分 类 号：O621.25[理学—有机化学]