自由基介导的串联环化反应构建七元含氮/氧杂环化合物  

Radical-Mediated Tandem Cyclization to Construct Seven-Membered Nitrogen/Oxygen Heterocycles

作　　者：赵晓伟 夏紫琴 张曼 周能能 Zhao Xiaowei;Xia Ziqin;Zhang Man;Zhou Nengneng(School of Chemistry and Materials Science,Anhui Normal University,Wuhu,Anhui 241002;School of Physics and Electronic Information,Anhui Normal University,Wuhu,Anhui 241002)

机构地区：[1]安徽师范大学化学与材料科学学院,安徽芜湖241002 [2]安徽师范大学物理与电子信息学院,安徽芜湖241002

出　　处：《有机化学》2022年第12期3995-4023,共29页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21901006)资助项目。

摘　　要：因为七元杂环骨架特殊的化学结构以及所含杂原子的独特化学性质使得其在天然产物及药物分子中得到广泛应用.然而,由于含氮/氧七元杂环骨架独特的热力学、动力学特征以及自身特有的跨环作用力等原因,使得针对这些结构的合成方法学的开发具有很强的挑战性.因此,发展简单、高效构筑七元杂环化合物的方法具有重要意义.相较于传统的合成方法,自由基反应可以避免较差的原子经济性和苛刻的反应条件的限制.综述了近年来利用自由基串联环化反应构建七元含氮/氧杂环化合物的合成策略.Owing to the special chemical structure of the seven-membered heterocyclic skeleton and the unique chemical properties of the heteroatoms contained,it is widely used in natural products and drug molecules.However,the development of synthetic methodology for these structures is challenging due to the unique thermodynamic and kinetic characteristics of nitrogen/oxygen-containing seven-membered heterocyclic frameworks,as well as their own unique cross-ring forces.Therefore,it is of great significance to develop simple and efficient methods for the construction of seven-membered heterocyclic compounds.Compared with traditional synthetic methods,radical reactions can avoid the limitations of poor atom economy and harsh reaction conditions.In this review,the recent synthetic strategies for the construction of seven-membered nitrogen/oxygen-containing heterocyclic compounds using radical tandem cyclization reactions are summarized.

关 键 词：自由基 串联环化反应 七元含氮杂环 七元含氧杂环 

分 类 号：O626[理学—有机化学] TQ460.1[理学—化学]