光/电催化下2-芳基-2H-吲唑C-3位的官能团化反应  

C-3 Functionalization of 2-Aryl-2H-indazoles under Photo/Electrocatalysis

作　　者：王丹凤 汪瑾 马春华 姜玉钦[1] 於兵 Wang Danfeng;Wang Jin;Ma Chunhua;Jiang Yuqin;Yu Bing(School of Chemistry and Chemical Engineering,Henan Normal University,Xinxiang,Henan 453007;College of Chemistry,Zhengzhou University,Zhengzhou 450001)

机构地区：[1]河南师范大学化学化工学院,河南新乡453007 [2]郑州大学化学学院,郑州450001

出　　处：《有机化学》2022年第12期4024-4036,共13页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.82003585,21971224);河南师范大学优秀科技创新团队(No.2022TD03);中国国家级大学生创新创业训练计划(No.202210476076)资助项目。

摘　　要：2H-吲唑是一种广泛存在于多种上市药物和活性分子中的优势骨架,对其骨架直接进行C—H键官能团化是构建其衍生物的有效方法之一,已经成为当前合成化学和药物化学的研究热点.相比传统的合成方法,可见光/电化学促进的合成方法条件温和,是一种环境友好的合成策略.本文以催化体系分类,综述了近年来光/电催化下2-芳基-2H-吲唑C-3位的官能团化反应,特别强调相应的反应机理,为进一步开发新型的催化方法奠定基础.2H-Indazole is a privileged scaffold widely existing in drugs and bioactive molecules.The C—H functionalization of 2H-indazole is the cutting edge in medicinal chemistry and organic chemistry.Compared with traditional synthetic methods,the visible light/electrochemical-promoted synthetic method has mild conditions and is an environmentally friendly synthetic strategy.The C—H functionalization of 2-aryl-2H-indazoles at the C-3 position catalyzed by photochemical/electrochemical strategies in recent years is summarized in terms of catalytic systems,with special emphasis on the corresponding reaction mechanism,which might inspire the further development of new catalytic methods.

关 键 词：2H-吲唑 官能团化 光催化 电催化 

分 类 号：O626[理学—有机化学] TQ460.1[理学—化学]