全碳体系的5-endo-Trig自由基环化反应研究进展  

Recent Advances on 5-endo-Trig Radical Cyclization of All-Carbon Systems

作　　者：郑汉良 苏静雯 周雨露 朱钢国 Zheng Hanliang;Su Jingwen;Zhou Yulu;Zhu Gangguo(Key Laboratory of the Ministry of Education for Advanced Catalysis Materials,Department of Chemistry,Zhejiang Normal University,Jinhua,Zhejiang 321004)

机构地区：[1]浙江师范大学化学系先进催化材料教育部重点实验室,浙江金华321004

出　　处：《有机化学》2022年第12期4060-4066,共7页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.22071218,22203076)资助项目。

摘　　要：5-endo-trig自由基环化是快速构筑五元环的理想方法之一.Baldwin-Beckwith规则指出,受立体电子效应影响,5-endo-trig自由基环化通常是动力学不利的.近年来,化学工作者一直致力于探索促进5-endo-trig自由基环化的新策略,以期发展高效、高选择性的五元碳环或杂环化合物的合成方法.综述了4-戊烯基自由基5-endo环化的最新进展,总结归纳了主要的促进策略,希望推动5-endo-trig自由基环化反应的进一步设计和发展.The 5-endo-trig radical closure has emerged as an ideal method for the fast aseembly of five-membered rings.It is believed to be kinetically disfavored due to the stereoelectronic disadvantages,so it is recognized as a disfavored process according to the Baldwin-Beckwith rules.Despite the challenges,continuous efforts have been devoted to develop effective strategies that enable 5-endo-trig radical cyclization.The recent advances on 5-endo-trig closure of 4-pentenyl radicals are summarized and the common strategies for accelerating the cyclization are analyzed,which will be valuable for the design and development of novel radical 5-endo-trig processes.

关 键 词：自由基 5-endo-trig环化 五元环 构象限制 极性效应 

分 类 号：O621.25[理学—有机化学]