氟烷基羧酸的脱羧氟烷基化反应研究进展  

Recent Advances in the Decarboxylative Fluoroalkylation of Fluoroalkyl Carboxylic Acids

作　　者：朱玉溪 肖婷 夏冬 杨文超 Zhu Yuxi;Xiao Ting;Xia Dong;Yang Wenchao(School of Plant Protection,Yangzhou University,Yangzhou,Jiangsu 225009;College of Pharmacy,Jiangsu Vocational College of Medicine,Yancheng,Jiangsu 224005;Guangling College,Yangzhou University,Yangzhou,Jiangsu 225009)

机构地区：[1]扬州大学植物保护学院,江苏扬州225009 [2]江苏医药职业学院药学院,江苏盐城224005 [3]扬州大学广陵学院,江苏扬州225009

出　　处：《有机化学》2022年第12期4067-4077,共11页Chinese Journal of Organic Chemistry

基　　金：江苏省高校自然科学基金(Nos.22KJB150051,19KJB150020)资助项目。

摘　　要：氟烷基羧酸衍生物的脱羧反应是获得氟烷基自由基的有效途径,而该自由基物种参与烯烃、异腈以及芳(杂)环的串联、加成反应是获取各种含氟官能化有机分子的重要方法.通过氟烷基羧酸产生的氟烷基自由基引发的串联反应可以构建啡啶、二氢黄酮、喹啉-2,4-二酮及吲哚酮等环状骨架.综述了近年来氟烷基羧酸脱羧引发的自由基反应的研究进展,涵盖反应设计、反应机理及研究展望等内容.Decarboxylation of fluoroalkyl carboxylic acid derivatives is an effective way to obtain fluoroalkyl radicals,which subsequently participates in the tandem and addition reactions of olefins,isonitriles and aromatic(hetero)rings,providing an important method to obtain divegent fluorine-containing molecules.A variety of fluoroalkyl cyclic compounds such as phenanthridines,dihydroflavonoid,quinolinones and indolones could be constructed using the tandem reaction initiated by fluoroalkyl radicals generated from fluoroalkyl carboxylic acids.The research progress of radical reactions induced by decarboxylation of fluoroalkyl carboxylic acids in recent years is summarized,which includes reaction design,reaction mechanism and outlook.

关 键 词：氟烷基化 脱羧反应 羧酸 

分 类 号：O621.25[理学—有机化学]