α-酮酸的脱羧酰基化/环化反应研究进展  

Recent Advances in the Decarboxylative Acylation/Cyclization ofα-Keto Acids

作　　者：吴业春 于金涛[1] Wu Yechun;Yu Jintao(School of Petrochemical Engineering,Changzhou University,Changzhou,Jiangsu 213164)

机构地区：[1]常州大学石油化工学院,江苏常州213164

出　　处：《有机化学》2022年第11期3606-3619,共14页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(No.21672028)资助项目。

摘　　要：酮酸的脱羧反应是得到酰基自由基的简便高效的方法,而连续的自由基环化反应是合成环状结构,特别是杂环结构的重要途径.通过α-酮酸脱羧产生酰基自由基引发的自由基环化反应,可以高效构建酰基化的吲哚酮、喹啉酮、菲啶、香豆素、色酮、苯并噻吩、吡咯[1,2-a]吲哚等结构.介绍了α-酮酸脱羧产生酰基自由基而引发的自由基历程的酰基化/环化反应的最新进展.Decarboxylation ofα-keto acids is a simple and efficient method to obtain corresponding acyl radicals.Cascade radical cyclization has been proved as efficient approach towards cyclic structures,especially heterocyclic ones.A variety of acylated cyclic compounds such as indolones,quinolinones,phenanthridines,coumarins,chromones,benzothiophenes,and pyrrole[1,2-a]indoles could be constructed usingα-keto acids via the decarboxylative acylation/cyclization with acyl radicals as intermediates.This review focuses on the recent advances in the acylation/cyclization reaction triggered by acyl radicals that formed from the decarboxylation ofα-keto acids.

关 键 词：酮酸 环化反应 自由基反应 酰基化 

分 类 号：O621.25[理学—有机化学]