监测微环境理化性质和活性硫物质的萘酰亚胺衍生物光学探针研究进展  

Research Progress of Naphthalimide Derivatives Optical Probes for Monitoring Physical and Chemical Properties of Microenvironment and Active Sulfur Substances

作　　者：夏鹏鹏 陈江太 施高凡 张蒙蒙 尧婉辰 林祥德 曾冬冬 Xia Pengpeng;Chen Jiangtai;Shi Gaofan;Zhang Mengmeng;Yao Wanchen;Lin Xiangde;Zeng Dongdong(School of Health Science and Engineering,University of Shanghai for Science and Technology,Shanghai 200093;Shanghai University of Medicine and Health Sciences,Shanghai 201318)

机构地区：[1]上海理工大学健康科学与工程学院,上海200093 [2]上海健康医学院,上海201318

出　　处：《有机化学》2022年第11期3620-3639,共20页Chinese Journal of Organic Chemistry

基　　金：上海市自然科学基金(No.19ZR1474300)资助项目。

摘　　要：萘酰亚胺衍生物具有出色的光物理特性,已被设计为光学探针并应用于各种生物学场景.作为生物学中重要的微环境和活性硫物质在生物系统中发挥着重要作用,有必要对其进行高效的检测.综述了萘酰亚胺衍生物探针对微环境和活性硫物质的检测.从pH值、粘度、极性和温度四个方面对微环境的检测进行阐述,讨论了探针的设计方案和各类荧光性能的比较.从检测策略角度把机制分为亲核取代策略、亲核加成策略、取代基的还原策略、重金属置换策略和其他策略,对活性硫物质进行论述,并对这些探针的各类荧光性能进行汇总与比较.最后,描述了这类探针的设计和实际应用中的一些不足,并对这一领域未来前景进行了展望.Naphthalimide derivatives have been designed as optical probes and applied in various biological scenarios due to their excellent photophysical properties.As an important microenvironment and active sulfur substance in biology plays an important role in biological system,it is necessary to detect it efficiently.The detection of naphthalimide derivatives for microenvironment and active sulfur substances is reviewed.The detection of microenvironment is described from four aspects of pH value,viscosity,polarity and temperature,and the design scheme of the probe and the comparison of all kinds of fluorescence properties are discussed.From the point of view of detection strategy,the mechanism is divided into nucleophilic substitution strategy,nucleophilic addition strategy,substituent reduction strategy,heavy metal replacement strategy and other strategies,and the fluorescence properties of these probes are summarized and compared.Finally,some shortcomings in the design and practical application of this kind of probe are described,and the future prospect of this field is prospected.

关 键 词：萘酰亚胺衍生物 微环境 活性硫物质 光学探针 光物理 

分 类 号：Q503[生物学—生物化学] O657.3[理学—分析化学]