高压氧联合人工周期治疗卵巢早衰对子宫内膜厚度和性激素水平的影响  

Effect of hyperbaric oxygen combined with artificial cycle on sexual hormones in the treatment of premature ovarian failure

作　　者：雷洁赟 王素琴[1] 刘萍[2] 王志启[3] 李慧[1] 李双雪[4] 雷垣生[5] 李峰 Lei Jieyun;Wang Suqin;Liu Ping;Wang Zhiqi;Li Hui;Li Shuangxue;Lei Yuansheng;Li Feng(Department of Gynecology,Shanxi Provincial People's Hospital,Taiyuan 030012,China;Department of Gynecology,Nanfang Hospital of Southern Medical University,Guangzhou 510515,China;Department of Gynecology,Peking University People's Hospital,Beijing 100044,China;Department of Respiratory Medicine,Shanxi Provincial People's Hospital,Taiyuan 030009,China;Department of Neurology,Second Hospital of Shanxi Medical University,Taiyuan 030013,China;Department of General Surgery,General Hospital of TISCO,Taiyuan 030008,China)

机构地区：[1]山西省人民医院妇科,太原030012 [2]南方医科大学南方医院妇科,广州510515 [3]北京大学人民医院妇科,北京100044 [4]山西省人民医院呼吸内科,太原030012 [5]山西医科大学第二医院神经内科,太原030001 [6]太钢总医院普外科,太原030008

出　　处：《中华航海医学与高气压医学杂志》2022年第6期808-812,共5页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

基　　金：国家卫生健康委“十三五”规划全国重点课题(YYWS2404)。

摘　　要：目的:探索高压氧联合人工周期雌孕激素序贯疗法治疗卵巢早衰的效果及对子宫内膜厚度和性激素水平的影响。方法:选取2019年2月至2020年12月山西省人民医院妇科收治的131例卵巢早衰患者为研究对象,按照随机数字表法分为对照组(66例)和观察组(65例)。对照组患者采用人工周期治疗,观察组患者采用高压氧联合人工周期治疗,比较各时间点性激素水平、子宫内膜厚度、窦卵泡数量、性功能指数(FSFI)评分以及疾病控制率。结果:治疗3个疗程后,2组患者的FSFI评分均明显升高,且观察组高于对照组,差异有统计学意义(P<0.05)。与治疗前相比,治疗3个疗程后2组患者的孕酮(P)、卵泡刺激素(FSH)、黄体生成素(LH)水平明显降低,雌二醇(E_(2))水平明显升高,且观察组血清E_(2)水平[(88.36±3.32)pmol/L]高于对照组[(79.39±4.45)pmol/L],P水平[(3.29±0.23)nmol/L]、FSH水平[(21.21±3.62)U/L]和LH水平[(25.23±1.12)U/L]均低于对照组[(4.86±0.54)nmol/L]、[(32.45±5.56)U/L]、[(32.11±1.32)U/L],差异均有统计学意义(P<0.05)。与治疗前相比,治疗3个疗程后2组患者的子宫内膜厚度明显降低,窦卵泡数量明显升高,且观察组高于对照组,差异有统计学意义(P<0.05)。观察组治疗2、3个疗程的疾病控制率均明显高于对照组(P<0.05)。结论:高压氧联合人工周期治疗卵巢早衰患者效果显著,相比于单方面使用人工周期,可更好地改善性激素水平,缩小子宫内膜厚度,提高整体治疗效果。Objective:To explore the effect of hyperbaric oxygen combined with artificial cycles treatment on premature ovarian failure(POF)and its influence on the thickness of the endometrium and hormone levels.Methods:A total of 131 patients with POF admitted to the Department of Gynecology of Shanxi Provincial People’s Hospital between February 2019 and December 2020 were selected and divided into control group(66 cases)and observation group(65 cases)according to the random number table method.Patients in the control group were treated with artificial cycles,and patients in the observation group were treated with hyperbaric oxygen combined with artificial cycles.Comparisons were made in terms of sex hormone levels,endometrial thickness,number of antral follicles,sexual function index(FSFI)scores,and disease control rates in each time period.Results:After three courses of treatment,the FSFI scores of both groups were increased,and the FSFI score in the observation group was significantly higher than that of the control group(P<0.05).The levels of progesterone(P),follicle stimulating hormone(FSH),and luteinizing hormone(LH)were significantly decreased,and the serum estradiol(E2)level was significantly increased.The E2 in the observation group was higher than that in the control group[(88.36±3.32)pmol/L>(79.39±4.45)pmol/L],the P,FSH,and LH levels in the observation group were lower than those in the control group[(3.29±0.23)nmol/L<(4.86±0.54)nmol/L,(21.21±3.62)IU/L<(32.45±5.56)IU/L,(25.23±1.12)IU/L<(32.11±1.32)IU/L,respectively],all with statistically significant differences(P<0.05).The thickness of endometrium in both groups was significantly reduced,and the number of antral follicles in both groups was significantly increased,and the antral follicles in the observation group was more than that in the control group,with statistically significant difference(P<0.05).Besides,the disease control rates of the observation group were higher than those of the control group after two and three courses of treatment(P<0.05)

关 键 词：高压氧 人工周期 卵巢早衰 子宫内膜厚度 性激素 

分 类 号：R711.75[医药卫生—妇产科学]