^(68)Ga-奥曲肽PET/CT显像患者对周围人群产生的有效剂量的估算  

Estimation of the effective dose of ^(68)Ga-Octreotide PET/CT imaging patients to the surrounding population

作　　者：潘永祥 王风[1] 丁立新 杨志[1] Pan Yongxiang;Wang Feng;Ding Lixin;Yang Zhi(Department of Nuclear Medicine,Peking University Cancer Hospital&Institute,NMPA Key Laboratory for Research and Evaluation of Radiopharmaceuticals(National Medical Products Administration),Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing),Beijing 100142,China)

机构地区：[1]北京大学肿瘤医院,北京市肿瘤防治研究所核医学科,国家药监局放射性药物研究与评价重点实验室,恶性肿瘤发病机制及转化研究教育部重点实验室,北京100142

出　　处：《国际放射医学核医学杂志》2022年第12期713-717,共5页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：国家自然科学基金(81871386);北京大学肿瘤医院学术骨干基金(2021-5)。

摘　　要：目的估算^(68)Ga-奥曲肽PET/CT显像患者对周围人群产生的有效剂量。方法采用简单随机抽样的方法选取2021年10至12月于北京大学肿瘤医院接受^(68)Ga-奥曲肽PET/CT显像的20例患者进行前瞻性研究,其中男性15例、女性5例,年龄30~68(49.0±12.2)岁。在患者静脉注射^(68)Ga-奥曲肽0 h后,使用辐射监测剂量仪测量距患者1.0 m处的空气吸收剂量率,注射1.0 h后测量距患者0.3 m处的空气吸收剂量率,注射1.5 h后测量距患者0.3、0.5、1.0和1.5 m处的空气吸收剂量率。依据美国国家辐射防护和测量委员会第155号报告提出的人类社会活动模式,采用积分法估算^(68)Ga-奥曲肽PET/CT显像患者对周围人群产生的有效剂量。结果注射^(68)Ga-奥曲肽0 h后,距患者1.0 m处的空气吸收剂量率为12.97~33.67(20.24±6.57)μSv/h;注射1.0 h后,距患者0.3 m处的空气吸收剂量率为32.73~57.69(48.98±6.20)μSv/h;注射1.5 h后,距患者0.3、0.5、1.0、1.5 m处的空气吸收剂量率分别为24.04~42.39(35.98±4.56)μSv/h、11.83~28.83(20.70±4.55)μSv/h、5.17~13.42(8.07±2.61)μSv/h、1.51~7.01(3.75±1.72)μSv/h。与^(68)Ga-奥曲肽显像患者白天接触的家庭成员受照的有效剂量为8.22~21.33(12.83±4.15)μSv,夜间同床共睡的家庭成员受照的有效剂量为38.92~68.62(58.25±7.38)μSv,单位同事受照的有效剂量为8.37~21.73(13.06±4.23)μSv,同车邻座乘客受照的有效剂量为32.97~58.15(49.36±6.26)μSv。每接触一例患者,操作人员受照的有效剂量为2.66~4.69(3.98±0.50)μSv,陪护护士受照的有效剂量为9.70~25.17(15.13±4.90)μSv。结论^(68)Ga-奥曲肽PET/CT显像患者对周围人群产生的有效剂量远低于国家标准规定的有效剂量限值。Objective To estimate the effective dose of ^(68)Ga-Octreotide PET/CT imaging patients to the surrounding population.Methods Twenty patients(15 males and 5 females,aged 30–68(49.0±12.2)years)who received ^(68)Ga-Octreotide PET/CT imaging at Peking University Cancer Hospital from October 2021 to December 2021 were randomly selected.After intravenous injection of ^(68)Ga-Octreotide,the air absorbed dose rate at 1 m away from the patient was measured by radiation monitoring dosimeter 0 h later,at 0.3 m away from the patient 1.0 h later,and at 0.3,0.5,1.0,and 1.5 m away from the patient 1.5 h later.Based on the patterns of human social activity proposed by the National Commission for Radiological Protection and Measurement No.155 report,integral method was used to estimate the effective dose of 8Ga-Octreotide PET/CT imaging patients to the surrounding population.Results Immediately after the injection of ^(68)Ga-Octreotide,the air absorbed dose rate at 1.0 m away from the patient was 12.97–33.67(20.24±6.57)μSv/h.At 1.0 h later,the air absorbed dose rate at 0.3 m away from the patient was 32.73–57.69(48.98±6.20)μSv/h.At 1.5 h later,the air absorbed dose rates at 0.3,0.5,1.0,and 1.5 m away from the patient were 24.04–42.39(35.98±4.56),11.83–28.83(20.70±4.55),5.17–13.42(8.07±2.61),and 1.51–7.01(3.75±1.72)μSv/h,respectively.The estimated effective doses were as follows:8.22–21.33(12.83±4.15)μSv to a family member exposed to the patients at the daytime;38.92–68.62(58.25±7.38)μSv to a family member who shared a bed at night with the patients;8.37–21.73(13.06±4.23)μSv to a colleague;and 32.97–58.15(49.36±6.26)μSv to an adjacent passenger.The radiation doses per ^(68)Ga-Octreotide PET/CT imaging patients was estimated to be 2.66–4.69(3.98±0.50)μSv to the operator and 9.70–25.17(15.13±4.90)μSv to the attending nurses.Conclusion The effective dose of ^(68)Ga Octreotide PET/CT imaging patients to the surrounding population is far lower than the effective dose limit specified in th

关 键 词：镓放射性同位素 奥曲肽 正电子发射断层显像术 体层摄影术 X线计算机 辐射防护 有效剂量 

分 类 号：R144[医药卫生—公共卫生与预防医学]