出 处:《新中医》2023年第3期99-102,共4页New Chinese Medicine
摘 要:目的:观察接骨七厘胶囊联合鹿瓜多肽治疗股骨颈骨折恢复期的临床疗效及对骨代谢指标的影响。方法:将60例股骨颈骨折恢复期患者按随机数字表法分为治疗组与对照组各30例,对照组给予鹿瓜多肽静脉注射治疗,治疗组联合接骨七厘胶囊治疗。比较2组治疗前后骨钙素(BGP)、骨形态发生蛋白-2(BMP-2)、碱性磷酸酶(ALP)、神经生长因子(NGF)、血小板衍生生长因子(PDGF)、胰岛素样生长因子-1 (IGF-1)水平及视觉模拟评分法(VAS)、Oswestry功能障碍指数问卷表(ODI)评分,比较2组临床疗效及不良反应发生情况。结果:治疗组总有效率96.67%,高于对照组76.67%(P<0.05)。治疗前,2组VAS、ODI评分及BMP-2、ALP、BGP、NGF、PDGF、IGF-1水平比较,差异无统计学意义(P>0.05);治疗后,2组VAS、ODI评分均降低(P<0.05),BMP-2、ALP、BGP、NGF、IGF-1、PDGF水平均升高(P<0.05),且治疗组VAS、ODI评分低于对照组(P<0.05),BMP-2、ALP、BGP、NGF、IGF-1、PDGF水平高于对照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:应用接骨七厘胶囊联合鹿瓜多肽治疗股骨颈骨折恢复期患者,临床疗效较好,骨折愈合较快,骨代谢指标和各细胞因子水平、功能障碍、疼痛得到明显改善。Objective:To observe the clinical effect of Jiegu Qili Capsules combined with Cervus and Cucumis Polypeptide on femoral neck fracture in convalescent stage and its effect on bone metabolic markers. Methods: A total of 60 cases with femoral neck fracture in convalescent stage were randomly divided into the treatment group and the control group,with 30 cases in each group. The control group was given intravenous injection with Cervus and Cucumis Polypeptide, and the treatment group was treated with Cervus and Cucumis Polypeptide combined with Jiegu Qili Capsules. Before and after treatment,the levels of osteocalcin(BGP),bone morphogenetic protein-2(BMP-2),alkaline phosphatase(ALP),nerve growth factor(NGF),platelet-derived growth factor(PDGF) and insulin-like growth factor-1(IGF-1) in both groups as well as the scores of Visual Analogue Scale(VAS) and Oswestry Disability Index(ODI) were compared. In addition, the clinical effects and incidence of adverse reactions in the two groups were compared. Results: The total effective rate was 96.67% in the treatment group, higher than that of 76.67% in the control group(P<0.05). Before treatment,there was no significant difference being found in the comparisons of scores of VAS,ODI and the levels of BMP-2,ALP,BGP,NGF,PDGF and IGF-1 between the two groups(P>0.05);after treatment,the scores of VAS and ODI in the two groups were decreased when compared with those before treatment(P<0.05), the levels of BMP-2, ALP, BGP,NGF,PDGF and IGF-1 in the two groups were increased(P<0.05),and the scores of VAS and ODI in the treatment group were lower than those in the control group(P<0.05),the levels of BMP-2,ALP,BGP,NGF,PDGF and IGF-1 in the treatment group were higher than those in the control group(P<0.05). There was no significant difference being found in the comparison of incidence of adverse reactions between the two groups(P>0.05). Conclusion:The therapy of Jieju Qili Capsules combined with Cervus and Cucumis Polypeptide has a good clinical effect on femoral neck fracture,which ca
关 键 词:股骨颈骨折恢复期 接骨七厘胶囊 鹿瓜多肽 骨代谢指标 视觉模拟评分法评分 Oswestry功能障碍指数问卷表
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...