补肾祛瘀方辅助治疗良性前列腺增生PVP术后患者临床研究  

Clinical Study on Bushen Quyu Formula Assisting Treatment for Patients After PVP for Benign Prostatic Hyperplasia

作　　者：李景远 周理 LI Jingyuan;ZHOU Li

机构地区：[1]南阳南石医院泌尿外科,河南南阳473000

出　　处：《新中医》2023年第3期103-107,共5页New Chinese Medicine

摘　　要：目的:观察补肾祛瘀方辅助治疗良性前列腺增生(BPH)经尿道选择性绿激光前列腺汽化术(PVP)术后患者的临床疗效及其对排尿功能、性激素水平的影响。方法:将120例BPH行PVP术后患者采用抽签法分为西药组和综合组各60例。西药组术后给予常规干预及盐酸坦洛新缓释片治疗,综合组在西药组基础上联合补肾祛瘀方治疗。比较2组临床疗效、症状改善情况、排尿功能、性激素水平及不良反应。结果:治疗前,2组国际前列腺症状评分(IPSS)、膀胱过度活动症评分(OABSS)比较,差异无统计学意义(P>0.05);治疗后,2组IPSS、OABSS评分均降低(P<0.05),且综合组低于西药组(P<0.05)。综合组临床总有效率95.00%,高于西药组81.67%(P<0.05)。治疗前,2组最大尿流率(Qmax)、残余尿量(PVR)、日间及夜间排尿次数、尿急次数比较,差异无统计学意义(P>0.05);治疗后,2组PVR、日间排尿次数、夜间排尿次数、尿急次数均减少(P<0.05),Qmax均增大(P<0.05),且综合组PVR、日间排尿次数、夜间排尿次数、尿急次数少于西药组(P<0.05),Qmax大于西药组(P<0.05)。治疗前,2组血清睾酮(T)、催乳素(PRL)、雌二醇(E_(2))、促黄体生成素(LH)水平比较,差异无统计学意义(P>0.05);治疗后,2组血清T、PRL水平升高(P<0.05),E_(2)、LH水平降低(P<0.05),且综合组血清T、PRL水平高于西药组(P<0.05),E_(2)、LH水平低于西药组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:补肾祛瘀方治疗BPH行PVP术后患者,可通过减轻尿道压力,改善排尿功能,改善症状,调控性激素水平,降低尿道刺激、胃肠道反应等不良反应的发生,提高临床疗效。Objective:To observe the clinical effect of Bushen Quyu Formula assisting treatment for patients after photoselective vaporization of the prostate(PVP)for benign prostatic hyperplasia(BPH)and its effect on urination function and levels of sex hormones.Methods:A total of 120 cases of patients with BPH after PVP were divided into the western medicine group and the comprehensive group according to the method of random sampling,with 60 cases in each group.After operation,the western medicine group was given routine intervention and Tamsulosin Hydrochloride Sustained-Release Tablets,and the comprehensive group was additionally treated with Bushen Quyu Formula based on the treatment of the western medicine group.The clinical effects,improvement of symptoms,urination function,levels of sex hormones and adverse reactions were compared between the two groups.Results:Before treatment,there was no significant difference being found in the comparison of scores of International Prostate Symptom Score(IPSS)and Overactive Bladder Symptom Score(OABSS)between the two groups(P>0.05).After treatment,the scores of IPSS and OABSS in the two groups were decreased when compared with those before treatment(P<0.05),and the scores in the comprehensive group were lower than those in the western medicine group(P<0.05).The total clinical effective rate was 95.00%in the comprehensive group,higher than that of 81.67%in the western medicine group(P<0.05).Before treatment,there was no significant difference being found in the comparison of maximal urinary flow rate(Qmax),post-void residual(PVR),frequency of urination during daytime and at night,and number of urgent urination between the two groups(P>0.05).After treatment,the PVR,frequency of urination during daytime and at night,and number of urgent urination were decreased in the two groups(P<0.05),and the Qmax was increased(P<0.05);the PVR,frequency of urination during daytime and at night,and number of urgent urination in the comprehensive group were less than those in the western medicine gr

关 键 词：良性前列腺增生 经尿道选择性绿激光前列腺汽化术 补肾祛瘀方 排尿功能 性激素 

分 类 号：R697.3[医药卫生—泌尿科学]