探讨呼出气一氧化氮测定在肺通气功能正常支气管哮喘患者中激素应答水平的应用研究  

Study on the Application of Hormone Response Level of Exhaled Breath Nitric Oxide Measurement in Bronchial Asthma Patients with Normal Lung Ventilation Function

作　　者：李玉红[1] 刘元元 魏红英[1] 曾静[1] LI Yu-hong;LIU Yuan-yuan;WEI Hong-ying(Depart-ment of Respiratory and Critical Care Medicine,Deyang People’s Hospital,Deyang,Sichuan,618000,China)

机构地区：[1]德阳市人民医院呼吸与危重症医学科,四川德阳618000

出　　处：《黑龙江医学》2023年第5期531-533,共3页Heilongjiang Medical Journal

基　　金：德阳市科技项目(2020SZZ110)。

摘　　要：目的:拟针对肺通气功能正常支气管哮喘患者进行呼出气一氧化氮测定(fractional exhaled nitric oxide,FeNO),研究FeNO测定对肺通气功能正常支气管哮喘患者糖皮质激素治疗的指导意义。方法:选取100例肺通气功能正常的支气管哮喘患者作为研究对象,纳入的奇数病例(50例)为对照组,偶数病例(50例)为试验组,分析FeNO浓度测定与哮喘症状控制之间的关系,对比两组患者激素治疗应答情况。结果:FeNO浓度测定与哮喘症状评分之间存在相关关系(P<0.05);两组患者激素治疗应答情况比较,差异有统计学意义(P<0.05)。结论:FeNO浓度测定可作为判断哮喘控制的参考依据,对于未控制与部分控制患者激素治疗有重要指导意义。Objective:Exhaled nitric oxide(FeNO) was measured in bronchial asthma patients with normal pulmonary ventilation to study the significance of FeNO measurement on glucocorticoid therapy in bronchial asthma patients with normal pulmonary ventilation.Methods:100 patients with bronchial asthma with normal pulmonary ventilation were selected for the study,and the odd-numbered cases(50 cases) included were the control group and the even-numbered cases(50 cases) were the test group.The relationship between FeNO concentration measurement on asthma symptom control was analyzed and the response to hormone therapy was compared between the two groups.Results:There was a correlation between FeNO concentration measurements and asthma symptom scores(P<0.05).The difference in response to hormone therapy between the two groups was statistically significant(P<0.05).Conclusion:FeNO concentration measurement can be used as a reference basis for determining asthma control,and is an important guide for hormone therapy in uncontrolled and partially controlled patients.

关 键 词：呼出气一氧化氮测定 肺通气正常 支气管哮喘患者 激素应答情况 

分 类 号：R562.2[医药卫生—呼吸系统]