Advances in the Transition Metal-Free C—H Trifluoromethylation  

作　　者：Demao Chen Jianwen Jiang Jie-Ping Wan 

机构地区：[1]Key Lab of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education,College of Chemistry and Chemical Engineering,Jiangxi Normal University,Nanchang,Jiangxi 330022,China.

出　　处：《Chinese Journal of Chemistry》2022年第21期2582-2594,共13页中国化学（英文版）

基　　金：supported by the Natural Science Foundation of Jiangxi Province(20202ACBL203006).

摘　　要：Trifluoromethyl group is one of the most frequently available and promising functional groups in pharmaceutical,agrochemical as well as material molecules.Developing synthetic methods for the synthesis of trifluoromethyl functionalized compounds by trifluoromethylation reactions occupies significant position in modern organic chemistry.On the other hand,as a typical tool of sustainable synthesis,transition metal-free synthesis possesses unique advantages in atom economy,easy product purification as well as excellent eco-tolerance.Consequently,transition metal-free trifluoromethylation reactions constitute the most important approaches for accessing trifluoromethylated molecules.Herein,the advances in the transition metal-free C—H trifluoromethylation reactions are reviewed for the first time.According to the updated state-of-art,both the catalytic reactions by conventional heating chemistry and the more sustainable photocatalysis are included,covering the trifluoromethylation reactions of C(sp^(3))–H bond,aromatic C(sp^(2))–H bond as well as the non-aromatic C(sp^(2))–H bond in different substrates over the last five years(2017—2021).

关 键 词：C-H bond TRIFLUOROMETHYLATION Transition metal-free THERMOCHEMISTRY PHOTOCATALYSIS 

分 类 号：O62[理学—有机化学]