间充质干细胞在组织修复和再生中应用的研究进展  

Advances in the application of mesenchymal stem cells in tissue repair and regeneration

作　　者：蔡海军(综述) 简华刚(审校)[1] CAI Haijun;JIAN Huagang(Department of Emergency Surgery,the Second Affiliated Hospital of Chongqing Medical University,Chongqing 400010,China)

机构地区：[1]重庆医科大学附属第二医院急诊外科,400010

出　　处：《重庆医学》2023年第5期782-786,共5页Chongqing medicine

基　　金：重庆市科卫联合医学科研项目(2021jstg028)。

摘　　要：近五十年来,间充质干细胞的生物医学应用得到了越来越多的关注。间充质干细胞是一种具有自我更新和分化成多种细胞类型能力的多系细胞,来源广泛,很容易从骨髓、脂肪、脐带和滑膜等组织中提取,在组织愈合和再生医学中发挥着关键作用,目前是组织修复和再生的研究热点。该文概述了间充质干细胞的起源和多种生物学特性及其相关临床研究与应用,为间充质干细胞在组织修复和再生的临床应用提供参考。In the last 50 years,the biomedical applications of mesenchymal stem cells(MSCs)have attracted increasing attention.MSCs are multilineage cells with the ability to self-renew and differentiate into multiple cell types from a wide variety of sources.They can be extracted easily from a variety of sources,including bone marrow,fat,umbilical cord,and synovial membrane,and play a key role in tissue healing and regenerative medicine,and are currently a hot research topic in tissue repair and regeneration.In this article,the origin and various biological characteristics of MSCs,and their relevant clinical research and applications were reviewed,which will provide reference for the clinical applications of MSCs in tissue repair and regeneration.

关 键 词：间充质干细胞 多向分化潜能 免疫调节 旁分泌 组织修复和再生 综述 

分 类 号：R632.1[医药卫生—外科学]