18F-氟代脱氧葡萄糖PET-CT定量参数与特发性间质性肺炎患者肺功能的关系探析  

Relationship Between Quantitative Parameters of 18F-Fluorodeoxyglucose PET-CT and Pulmonary Function in Patients With Idiopathic Interstitial Pneumonia

作　　者：赵杰 梁琰[1] 张晓 Zhao Jie;Liang Yan;Zhang Xiao(Department of Nuclear Medicine,Sanmenxia Central Hospital,Sanmenxia 472000,China)

机构地区：[1]三门峡市中心医院核医学科,河南三门峡472000

出　　处：《哈尔滨医药》2023年第1期14-16,共3页Harbin Medical Journal

摘　　要：目的探讨18F-氟代脱氧葡萄糖(18F-FDG)PET-CT定量参数与特发性间质性肺炎(IIP)患者肺功能的关系。方法回顾性分析25例在我院确诊并治疗的IIP患者为观察组,并选取同期健康体检肺功能正常患者25例为对照组,比较两组性别、年龄、病程等一般资料,比较不同肺功能水平患者的PET-CT定量参数水平,Pearson相关性分析PET-CT定量参数水平与肺功能严重程度关系。结果两组患者比较性别、年龄、病程、体质量指数(BMI)、吸烟史和文化程度一般资料差异无统计学意义(P>0.05);1秒用力呼气容积(FEV1%)降低,PaO_(2)越小,肺功能分级(GOLD)越高,病灶最大直径越大,最大标准摄取值(SUVmax)越小(P<0.05);Pearson相关性分析显示,病灶最大直径与PaO_(2)、FEV1%呈负相关,与GOLD呈正相关(P<0.05),SUVmax与FEV1%、PaO_(2)呈正相关,与GOLD呈负相关(P<0.05)。结论PET-CT定量参数病灶最大直径、SUVmax与IIP患者肺功能有关,临床医师可以此评估病情进展。Objective To explore the relationship between quantitative parameters of 18F-fluorodeoxyglucose(18F-FDG)PET-CT and pulmonary function of patients with idiopathic interstitial pneumonia (IIP).Methods 25 patients with IIP diagnosed and treated in our hospital were retrospectively analyzed as the observation group,and 25 patients with normal lung function in the same period were selected as the control group.The general data such as gender,age and course of disease were compared between the two groups.The quantitative parameters of PET-CT in patients with different lung function levels were compared,and Pearson correlation analysis was used to analyze the relationship between the quantitative parameters of PET-CT and the severity of lung function.Results There was no significant difference in general data of sex,age,course of disease,body mass index (BMI),smoking history and education level between the two groups (P>0.05).The forced expiratory volume per second(FEV1%)decreases,the smaller PaO_(2) is,the higher the lung function grade(GOLD)is.The larger the maximum diameter of the lesion,the smaller the maximum standard uptake value (SUVmax P<0.05).Pearson correlation analysis showed that the maximum diameter of lesions was negatively correlated with PaO2 and FEV1%,positively correlated with GOLD(P<0.05),and SUVmaxwas positively correlated with FEV1% and PaO2,negatively correlated with GOLD(P<0.05).Conclusion The quantitative parameters of PET-CT,such as the maximum lesion diameter and SUVmax,are related to the lung function of IIP patients,and clinicians can evaluate the progress of the disease.

关 键 词：18F-氟代脱氧葡萄糖 PET-CT定量参数 

分 类 号：R563.1[医药卫生—呼吸系统]