肾脏病患者血清过敏原检测结果分析研究  

Analysis on the test result of serum allergen in patients with kidney disease

作　　者：毕胜[1] 朱红艳[1] 沈燕迪 余亚玲 BI Sheng;ZHU Hongyan;SHEN Yandi;YU Yaling(Department of Clinical Laboratory,The First People's Hospital of Yunnan Province/Affiliated Hospital of Kunming University of Science and Technology,Kunming Yunnan 650032,Chin;Department of Nephrology,The First People's Hospital of Yunnan Province/Affiliated Hospital of Kunming University of Science and Technology,Kunming Yunnan 650032,China)

机构地区：[1]云南省第一人民医院/昆明理工大学附属医院检验科,云南昆明650032 [2]云南省第一人民医院/昆明理工大学附属医院肾内科,云南昆明650032

出　　处：《云南医药》2023年第1期31-34,共4页Medicine and Pharmacy of Yunnan

摘　　要：目的探讨肾脏病患者食入性及吸入性过敏原分布情况。方法采用免疫印迹方法对296例肾脏病患者和156例正常对照者的血清进行食入性及吸入性过敏原检测。结果肾脏病患者中食入性与吸入性过敏原阳性者占70.3%(208/296);对照组中过敏原阳性者占31.4%(49/156),2组间差异有统计学意义(χ^(2)=62.892,P<0.001);过敏原阳性肾脏病患者中以NS患者最多,占27.9%(58/208),其次是CRF患者和IgA肾病患者,分别占26.4%(55/208)和11.1%(23/208)。过敏原阴性肾脏病患者中CRF患者最多,占40.9%(36/88),其次是NS患者,占14.8%(13/88),2组病人间差异有统计学意义(χ^(2)=14.496,P=0.043)。同一种疾病过敏原阳性与阴性病人数量比值最高的是IgA肾病和NS患者(4.6 VS 4.5);肾脏病人血清过敏原阳性患者中,最常见的过敏原是户尘螨占76.4%(159/208)、其次是蟑螂占58.7%(122/208)及腰果占38.5%(80/208)。结论肾脏病患者尤其是IgA肾病和肾病综合征患者中过敏原阳性患者比较常见,户尘螨和蟑螂是该地区肾病患者中最常见的过敏原。因此,对于肾脏病患者应常规进行血清过敏原检测筛查。Objective To investigate the distribution of ingestion and inhalation allergens in patients with kidney diseases.Methods Detection of ingestion and inhalation allergens in serum of 296 patients with kidney disease and 156 normal controls by imomunoblotting.Results 70.3%(208/296)of nephrotic patients were positive for ingestion and inhalation allergens;31.4%(49/156)of the control group were positive for allergens,with statistical significance in the difference between the two groups(χ^(2)=62.892,P<0.001);The majority of patients with allergen positive kidney disease were NS patients(27.9%(58/208),followed by CRF patients and IgA nephropathy patients,accounted 26.4%(55/208)and 11.1%(11/208)respectively.The majority of patients with allergen-negative nephropathy were CRF patients,accounted for 40.9%(36/88),followed by NS(14.8%(13/88),there was statistical significance in the difference between the two groups(χ^(2)=14.496,P=0.043).The highest ratio of positive to negative allergens in the same disease was IgA nephropathy and NS patients(4.6 VS 4.5).In patients with kidney disease who were serum allergen positive,the most common allergens were dust mites 76.4%(159/208),cockroaches 58.7%(122/208)and cashew nuts 38.5(80/208).Conclusions Allergen-positive are common in patients with kidney disease,especially IgA nephropathy and nephrotic syndrome patients.House dust mites and cockroaches are the most common allergens in nephrotic patients in this area.Therefore,serum allergen detection and screening should be routinely carried out in patients with nephropathy.

关 键 词：肾脏疾病 食入性过敏原 吸入性过敏原 过敏反应 

分 类 号：R446.6[医药卫生—诊断学]