橡胶防老化剂6PPD及其臭氧化产物6PPD-Q的环境分布和生物毒性  

Rubber anti-aging agent 6PPD and its ozonation product 6-PPDQ:Environmental distribution and biological toxicity

作　　者：李嘉瑶 申慧敏 徐婷婷 郭英 LI Jia-yao;SHEN Hui-min;XU Ting-ting;GUO Ying(Guangdong Key Laboratory of Environmental Pollution and Health,School of Environment,Jinan University,Guangzhou 510632,China)

机构地区：[1]暨南大学环境学院,广东省环境污染与健康重点实验室,广东广州510632

出　　处：《中国环境科学》2023年第3期1407-1421,共15页China Environmental Science

基　　金：国家自然科学基金资助项目(2217060029)。

摘　　要：本文总结了6PPD-Q(N-(1,3-二甲基丁基)-N’-苯基对苯醌)及其前体物质6PPD(N-(1,3-二甲基丁基)-N’-苯基对苯二胺)在环境介质大气、水体、土壤中的来源及其分布情况,并陈述了6PPD和6PPD-Q相关的细胞毒性、生物毒性研究进展,以及对人类健康可能的影响等.现有研究表明,6PPD和6PPD-Q主要源于橡胶轮胎磨损颗粒物,可附着于大气细颗粒物在大气、水体和土壤中迁移;具有细胞毒性,可抑制细胞增殖;具有生物毒性,对某些种类的鲑鱼造成急性毒性,并产生发育毒性;能够引起人体产生过敏性皮炎等.今后应深入研究6PPD和6PPD-Q与其他橡胶轮胎添加剂的联合毒性作用及其有关的生态风险评价.In the present review,we discussed the environmental distribution of 6PPD-quinone(N-(1,3-dimethylbutyl)-N’-phenyl-p-phenylenediamine quinone)and its precursor 6PPD(N-(1,3-Dimethyl-butyl)-N’-phenyl-p-phenylenediamine)in the air,aquatic environment,and soil,and summarized their cytotoxicity and biota toxicity,as well as potential effect on human health.The present knowledge indicated that 6PPD and 6PPD-Q are mainly from the rubber tire wear particles.They are transported with particles in air,water and soil.6PPD and 6PPD-Q may inhibit cell proliferation,cause acute death of several fish species,and induce developmental toxicity,and may induce allergic dermatitis for humans.The future researches should pay more attention on the joint toxicity of 6PPD and 6PPD-Q with other rubber tire additives,and the related ecological risk assessment.

关 键 词：6PPD 6PPD-quinone 环境分布 生物毒性 橡胶轮胎磨损颗粒物 

分 类 号：X503[环境科学与工程—环境工程]