血清VEGF、bFGF与阶梯式降压配合引流术治疗慢性硬膜下血肿患者脑组织恢复相关性  

Correlation between serum VEGF,bFGF and brain tissue recovery in patients with chronic subdural hematoma treated by stepwise decompression and drainage

作　　者：曹子轩 王冬杰[2] 祁晓花 CAO Zixuan;WANG Dongjie;QI Xiaohua(Department of Neurosurgery,Hebei Langfang People's Hospital,Langfang,Hebei,China,065000;Langfang Health Vocational College,Langfang,Hebei,China,065000;Fourth People's Hospital of Langfang,Imaging Department,Langfang,Hebei,China,065000)

机构地区：[1]河北省廊坊市人民医院神经外科,河北廊坊065000 [2]河北省廊坊卫生职业学院,河北廊坊065000 [3]河北省廊坊市第四人民医院影像科,河北廊坊065000

出　　处：《分子诊断与治疗杂志》2023年第1期22-25,共4页Journal of Molecular Diagnostics and Therapy

基　　金：廊坊市科学技术局项目(2018013119)。

摘　　要：目的 探讨血清血管内皮生长因子(VEGF)、碱性成纤维细胞生长因子(bFGF)与阶梯式降压配合引流术治疗慢性硬膜下血肿患者脑组织恢复相关性。方法 选取2020年1月至2021年12月于廊坊市人民医院神经外科住院就诊的104例慢性硬膜下血肿患者作为研究对象。所有患者应用阶梯式降压配合引流术治疗,分别于术前1 d、术后24 h、术后7 d检测其血清VEGF、bFGF,测量各时间点初发血肿最宽径、最长径以及脑组织与颅骨内板距离。分析血清VEGF、bFGF与患者术后脑组织恢复的相关性。结果 与术前1 d比,术后24 h及术后7 d患者血清VEGF、bFGF水平均降低,不同时间点血清VEGF、bFGF水平比较,差异有统计学意义(F=551.173、220.390,P<0.05);术后24 h及术后7 d患者初发血肿最宽径、初发血肿最长径、脑组织与颅骨内板间隙均减小,不同时间点初发血肿最宽径、初发血肿最长径、脑组织与颅骨内板间隙比较,差异有统计学意义(F=821.742、1 666.733、880.132,P<0.05);术后7 d时血清VEGF、bFGF与初发血肿最宽径、初发血肿最长径、脑组织与颅骨内板间隙均呈正相关(P<0.05)。结论慢性硬膜下血肿患者阶梯式降压配合引流术治疗效果良好,血清VEGF、bFGF与脑组织的恢复呈正相关。Objective To investigate the correlation between serum vascular endothelial growth factor(VEGF),basic fibroblast growth factor(bFGF)and brain tissue recovery in patients with chronic subdural hematoma treated by stepwise decompression combined with drainage. Methods From January 2020 to December 2021,104 patients with chronic subdural hematoma who were hospitalized at the Department of Neurosurgery of Langfang People’s Hospital were selected as the research subjects. All patients treated with stepwise hypotension combined with drainage. Serum VEGF and bFGF were detected at 1 day before operation,1 day and 7 days after operation. The distance between the brain tissue and the inner plate of the skull,the correlation between serum VEGF,b FGF and postoperative brain tissue recovery of patients was analyzed.Results Compared with the 1 day before operation,the serum VEGF and bFGF levels of patients at 1 day and 7 days after operation were all lower,and the serum VEGF and bFGF levels at different time points were significantly different(F=551.173,220.390,P<0.05). The widest diameter of the initial hematoma,the longest diameter of the initial hematoma,and the gap between the brain tissue and the inner plate of the skull were all reduced at 1 day and 7 days after operation. There are statistically significant differences in the widest diameter of the initial hematoma,the longest diameter of the initial hematoma,and the gap between the brain tissue and the inner plate of the skull at different time points(F=821.742,1 666.733,880.132,P<0.05). At 7 days after operation,serum VEGF and bFGF were positively correlated with the widest diameter of the initial hematoma,the longest diameter of the initial hematoma,and the gap between the brain tissue and the inner plate of the skull(P<0.05). Conclusion The effect of step-wise blood pressure reduction combined with drainage in patients with chronic subdural hematoma is good,and serum VEGF,bFGF are positively correlated with the recovery of brain tissue.

关 键 词：血管内皮生长因子 碱性成纤维细胞生长因子 阶梯式降压配合引流术 慢性硬膜下血肿 脑组织恢复 

分 类 号：R651.15[医药卫生—外科学]