血清GMP-140、sCD40L表达与重症肺炎预后的相关性  

Correlation between the expression of serum GMP-140 and sCD40L and the prognosis of severe pneumonia

作　　者：陈燕雄 庄晓虹 林映碧 赵贤武[3] CHEN Yanxiong;ZHUANG Xiaohong;LIN Yingbi;ZHAO Xianwu(Department of Emergency,Dafeng Hospital,Chaoyang District,Shantou,Guangdong,China,515100;Department of Critical Care Medicine,Dafeng Hospital,Chaoyang District,Shantou,Guangdong,China,515100;Department of EICU,Shantou Central Hospital,Guangdong,China,515100)

机构地区：[1]汕头市潮阳区大峰医院急诊科,广东汕头515100 [2]汕头市潮阳区大峰医院重症医学科,广东汕头515100 [3]汕头市中心医院EICU科,广东汕头515000

出　　处：《分子诊断与治疗杂志》2023年第1期48-51,55,共5页Journal of Molecular Diagnostics and Therapy

基　　金：汕头市科技计划医疗卫生项目(190403105260671)。

摘　　要：目的 探究重症肺炎患者氧化应激和可溶性CD40配体(sCD40L)、血小板α-颗粒膜糖蛋白140(GMP-140)表达及与预后关系。方法 选取2016年7月至2018年3月汕头市潮阳区大峰医院呼吸科收治的84例肺炎患者为研究对象,依据症状严重程度分为重症肺炎组、非重症肺炎组,选取同期健康体检者50名为对照组。检测受试者sCD40L、GMP-140水平,采用二元Logistic回归分析肺炎严重程度影响因素,采用受试者工作曲线(ROC)分析sCD40L、GMP-140水平对预后的预测价值。结果sCD40L、GMP-140水平:重症肺炎组>非重症肺炎组>健康对照组,存活组患者sCD40L、GMP-140表达水平均低于死亡组,差异有统计学意义(P<0.05)。sCD40L、GMP-140是肺炎病情影响因素,sCD40L、GMP-140预测肺炎患者死亡曲线下面积(AUG)为0.837、0.771。结论sCD40L、GMP-140在重症肺炎患者体内存在异常高表达,是重症肺炎患者的影响因素,对临床预测肺炎患者预后有一定应用价值。Objective To explore oxidative stress,soluble CD40 ligand(sCD40L)and platelets in patients with severe pneumonia α-The expression of granule membrane glycoprotein 140(GMP-140)and its relationship with prognosis. Methods 84 patients with pneumonia admitted to the Respiratory Department of Dafeng Hospital,Chaoyang District,and Shantou City from July 2016 to March 2018 were selected as the study subjects. They were divided into the severe pneumonia group(40 cases)and the non-severe pneumonia group(44 cases)according to the severity of symptoms,and 50 health examinees in the same period were selected as the control group. According to the survival and death of patients with pneumonia during treatment and within one month after treatment,they were divided into the survival group of 71 cases and the death group of13 cases. The levels of s CD40L and GMP-140 in the subjects were detected,and the influencing factors of pneumonia severity were analyzed by binary Logistic regression. The predictive value of sCD40L and GMP-140 levels on prognosis was analyzed by receiver operating curve(ROC). Results The levels of sCD40L and GMP-140 in the severe pneumonia group were higher than those in the non-severe pneumonia group. The levels of sCD40L and GMP-140 in the survival group were lower than those in the death group,with statistical significance(P<0.05). SCD40L and GMP-140 are the influencing factors of pneumonia. The levels of sCD40L and GMP-140 predict the area under the death curve(AUG) of pneumonia patients to be 0.837 and 0.771.Conclusion The abnormally high expression of sCD40L and GMP-140 in patients with severe pneumonia is an influencing factor for patients with severe pneumonia,and it has certain application value in predicting the prognosis of patients with pneumonia.

关 键 词：肺炎 严重程度 氧化应激和可溶性CD40配体 血小板α-颗粒膜糖蛋白140 预后 

分 类 号：R563.1[医药卫生—呼吸系统]