循环促红细胞生成素对DN患者肾功能快速下降风险的预测价值  

Predictive value of circulating erythropoietin on the risk of rapid decline in renal function in patients with DN

作　　者：廖春燕[1] 谭振宇[2] 黄洁 李丽[1] LIAO Chunyan;TAN Zhenyu;HUANG Jie;LI li(Department of Endocrinology,People's Hospital of Bao'an District,Shenzhen,Guangdong Province,Shenzhen,Guangdong,China,518101;Department of Cardiovascular Medicine,Baoan District People's Hospital,Shenzhen,Guangdong,China,518101)

机构地区：[1]广东省深圳市宝安区人民医院内分泌内科,广东深圳518101 [2]广东省深圳市宝安区人民医院心血管内科,广东深圳518101

出　　处：《分子诊断与治疗杂志》2023年第1期173-176,共4页Journal of Molecular Diagnostics and Therapy

基　　金：广东省医学科学技术研究基金项目(C2018053)。

摘　　要：目的 探讨循环促红细胞生成素对糖尿病肾病(DN)患者肾功能快速下降风险的预测价值。方法 选取2018年1月至2020年9月于广东省深圳市宝安区人民医院就诊的176例DN患者的临床资料。收集患者入院时促红细胞生成素水平;根据患者肾功能是否快速下降分为下降组(45例)和未下降组(131例)。分析促红细胞生成素水平预测DN患者肾功能快速下降风险的价值。结果 下降组血红蛋白、铁蛋白、循环促红细胞生成素、CRP与未下降组比较差异有统计学意义(P<0.05);logistic回归分析显示血红蛋白(OR=2.388)、铁蛋白(OR=0.836)、循环促红细胞生成素(OR=3.431)、CRP(OR=0.008)是DN患者肾功能快速下降的影响因素(P<0.05),ROC曲线分析显示循环促红细胞生成素预测DN患者肾功能快速下降的曲线下面积为0.823,Delong法比较显示循环促红细胞生成素AUC高于血红蛋白、铁蛋白、CRP。结论 循环促红细胞生成素与DN患者肾功能快速下降,可用于DN患者肾功能快速下降的预测,血红蛋白、铁蛋白、CRP也为DN患者肾功能快速下降的影响因素。Objective To explore the predictive value of circulating erythropoietin on the risk of rapid decline in renal function in patients with diabetic nephropathy(DN). Methods The clinical data of 176DN patients who were treated in Shenzhen Baoan District People’s Hospital from January 2018 to September2020 were retrospectively selected. The erythropoietin levels of the patients upon admission were collected;according to whether the renal function of the patients decreased rapidly,they were divided into a decreased group(45 cases)and a non-decreased group(131 cases). The value of erythropoietin level in predicting the risk of rapid decline in renal function in patients with DN was analyzed. Results The decreased group showed significant differences in hemoglobin,ferritin,circulating erythropoietin,and CRP compared with the non-decreased group(P<0.05). Logistic regression analysis showed that hemoglobin(OR=2.388)and ferritin(OR=0.836),circulating erythropoietin(OR=3.431),and CRP(OR=0.008)are the influencing factors of the rapid decline of renal function in DN patients(P<0.05). ROC curve analysis showed that the area under the curve of circulating erythropoietin predicting rapid decline in renal function in patients with DN was 0.823. Comparison by Delong method showed that the AUC of circulating erythropoietin was higher than that of hemoglobin,ferritin and CRP. Conclusion Circulating erythropoietin and the rapid decline of renal function in patients with DN can be used to predict the rapid decline of renal function in patients with DN. Hemoglobin,ferritin,and CRP are also influencing factors for the rapid decline of renal function in DN patients.

关 键 词：循环促红细胞生成素 糖尿病肾病 肾功能 预测价值 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]