不孕妇女解脲支原体感染血清自身抗体及宫颈黏液炎症因子水平  

Serum autoantibodies and cervical mucus inflammatory factors in infertile women with Ureaplasma urealyticum infection

作　　者：温晶 张嵩卉[2] 王晓宇 李丹 郑梅 WEN Jing;ZHANG Song-hui;WANG Xiao-yu;LI Dan;ZHENG Mei(Haikou Maternal and Child Health Hospital,Haikou,Hainan 570203,China)

机构地区：[1]海口市妇幼保健院生殖医学中心,海南海口570203 [2]广州医科大学附属第二医院产科,广东广州510300 [3]齐齐哈尔建华医院妇科,黑龙江齐齐哈尔161006

出　　处：《中华医院感染学杂志》2023年第4期598-601,共4页Chinese Journal of Nosocomiology

基　　金：海南省科技计划基金资助项目(813265)。

摘　　要：目的 分析不孕妇女解脲支原体(UU)血清自身抗体及宫颈黏液炎症因子水平.方法 选取2019年10月-2021年10月于海口市妇幼保健院生殖医学中心就诊的80例合并UU感染的不孕症患者作为研究组,选取同期未合并UU感染的不孕症患者100例作为对照组,比较两组患者基础资料及排卵期血清抗人绒毛膜促性腺激素抗体(HCG-Ab)、抗精子抗体(As-Ab)、抗卵巢抗体(AO-Ab)、抗子宫内膜抗体(AEM-Ab)、抗心磷脂抗体(AC-Ab)表达情况及宫颈黏液肿瘤坏死因子-α(TNF-α)、干扰素-γ(IFN-γ)、白细胞介素-6(IL-6)、IL-8水平.结果 研究组患者自然流产史占比23.75%(19/80)高于对照组(P<0.05);研究组患者血清As-Ab、AO-Ab、AEM-Ab阳性率为 61.25%(49/80)、22.50%(18/80)、48.75%(39/80),均高于对照组(P<0.05);研究组患者宫颈黏液中的 TNF-α、IFN-γ、IL-6、IL-8 水平分别为(175.68±36.12)ng/ml、(79.61±8.26)ng/ml、(0.35±0.23)pg/ml、(0.93±0.37)pg/ml均高于对照组(P<0.05).结论 不孕症妇女合并UU感染血清自身抗体阳性率和宫颈黏液炎症因子水平较高,UU可能通过诱导自身抗体表达和宫颈组织炎症损害参与了不孕症的病理过程.OBJECTIVE To analyze the levels of serum autoantibodies and cervical mucus inflammatory factors in infertile women with Urea plasma ureal yticum(UU)infection.METHODS Totally 80 infertile patients with combined UU infection treated in the Reproductive Medicine Center of Haikou Maternal and Child Health Hospital from Oct.2019 to Oct.2021 were selected as the study group,and 100 infertile patients without combined UU infection during the same period were selected as the control group.The basic data and the expressions of serum anti human chorionic gonadotropin antibody(HCG-Ab)and antisperm antibody(AS-Ab),antiovarian antibody(AOAb),antiendometrial antibody(AEM-Ab),anticardiolipin antibody(AC-Ab)as well as the tumor necrosis factor(TNF)-α,interferon-γ(IFN)-γ,interleukin(IL)-6,IL-8 in cervical mucus during ovulation of patients in the two groups were compared.RESULTS The percentage of the patients with spontaneous abortion in the study group was 23.75%(19/80),which was higher than that in the control group(P<0.05).The positive rates of serum AS-Ab,AO-Ab andAEM-Abof the patients in thestudygroupwere 61.25%(49/80),22.50%(18/80)and 48.75%(39/80),respectively,all higher than those in the control group(P<0.05).The levels of TNF-α,IFN-γ,IL-6andIL-8incervicalmucuswere(175.68±36.12)ng/ml,(79.61±8.26)ng/ml,(0.35±0.23)pg/ml and(0.93±0.37)pg/ml,respectively,all higher than those in the control group(P<0.05).CONCLUSION Infertile women with co-infected UU had higher rates of positive serum autoantibodies and higher levels of inflammatory factors in cervical mucus.UU might be involved in the pathological process of infertility by inducing the expression of autoantibodies and inflammatory damage of cervical tissue.

关 键 词：不孕症 解脲支原体 感染 自身抗体 宫颈黏液 炎症因子 

分 类 号：R375[医药卫生—病原生物学]