小剂量阿司匹林联合拉贝洛尔治疗子痫前期的疗效研究  

Efficacy of Low-Dose Aspirin Combined with Labetalol in the Treatment of Pre-eclampsia

作　　者：王盈红[1] 钮慧远[1] 郑晓晓 戚婷婷[1] 朱晓琴[3] 姜玲 WANG Yinghong;NIU Huiyuan;ZHENG Xiaoxiao;QI Tingting;ZHU Xiaoqin;JIANG Ling(Dept.of Obstetrics,Huai’an Maternal and Child Health Hospital,Jiangsu Huai’an 223002,China;Dept.of Emergency,Huaian Maternal and Child Health Hospital,Jiangsu Huai’an 223002,China;Dept.of Women's Healthcare,Huai’an Maternal and Child Health Hospital,Jiangsu Huai’an 223002,China)

机构地区：[1]淮安市妇幼保健院产科,江苏淮安223002 [2]淮安市妇幼保健院急诊科,江苏淮安223002 [3]淮安市妇幼保健院妇女保健科,江苏淮安223002

出　　处：《中国医院用药评价与分析》2023年第2期208-211,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：江苏省中医药管理局中医药科技发展中心项目(No.ZX2020A1-16);江苏省妇幼健康科研项目(No.F201932)。

摘　　要：目的:探讨小剂量阿司匹林分别联合拉贝洛尔、硝苯地平对子痫前期患者疗效的影响。方法:前瞻性选取2021年2—12月于该院治疗的254例子痫前期患者,依据随机数字表法分为对照组(127例)、观察组(127例)。观察组患者采用盐酸拉贝洛尔片联合小剂量阿司匹林片治疗,对照组患者采用硝苯地平缓释片联合小剂量阿司匹林片治疗。观察并比较两组患者的治疗效果,治疗前后血清胱抑素C(CysC)、血流动力学指标(血液黏度、红细胞比容、心脏指数)水平,不良妊娠结局(宫内窘迫、新生儿窒息、宫缩乏力、产后出血、剖宫产、早产儿)以及不良反应(恶心、呕吐、肌无力、腹痛)。对比分析阿司匹林联合拉贝洛尔或硝苯地平在子痫前期治疗中的应用价值。结果:与对照组相比(88.98%,113/127),观察组患者的治疗总有效率(96.85%,123/127)明显更高,差异有统计学意义(P<0.05)。治疗后,与对照组相比,观察组患者的CysC水平更低,差异有统计学意义(P<0.05)。治疗后,两组患者的血液黏度、红细胞比容、心脏指数均较治疗前改善;且观察组患者的血液黏度、红细胞比容低于对照组,心脏指数高于对照组,差异均有统计学意义(P<0.05)。与对照组相比,观察组患者的不良妊娠结局总发生率(17.32%,22/127)低于对照组(28.35%,36/127),不良反应总发生率(2.36%,3/127)低于对照组(11.02%,14/127),差异均有统计学意义(P<0.05)。结论:与小剂量阿司匹林联合硝苯地平相比,小剂量阿司匹林联合拉贝洛尔治疗子痫前期效果更好,在未增加不良反应的情况下,对患者肾功能、血流动力学的改善效果更明显,且出现不良妊娠结局的概率更低。OBJECTIVE:To probe into the effect of low-dose aspirin combined with labetalol and nifedipine on the efficacy in the treatment of pre-eclampsia.METHODS:Totally 254 patients with pre-eclampsia admitted into Huai’an Maternal and Child Health Hospital from Feb.2021 to Dec.2021 were prospectively selected and divided into control group and observation group by random number table method,with 127 patients in each group.The observation group was given Labetalol hydrochloride tablets combined with low-dose aspirin tablets,while the control group was given Nifedipine sustained-release tablets combined with low-dose aspirin tablets.The therapeutic effects,serum cystatin C(CysC),hemodynamic indexes(blood viscosity,hematocrit value,cardiac index),adverse pregnancy outcomes(intrauterine distress,neonatal asphyxia,uterine inertia,postpartum hemorrhage,cesarean section,premature infants),adverse drug reactions(nausea,vomiting,myasthenia,abdominal pain)were observed and compared between two groups before and after treatment.To compare and analyze the application value of aspirin combined with labetalol or nifedipine in the treatment of pre-eclampsia.RESULTS:Compared with the control group(88.98%,113/127),the total effective rate of the observation group(96.85%,123/127)was significantly higher,with statistically significant difference(P<0.05).After treatment,the CysC level of the observation group lower than that of the control group,with statistically significant difference(P<0.05).After treatment,the blood viscosity,hematocrit value and cardiac index of both groups had been improved than those before treatment;the blood viscosity and hematocrit value were lower,and the cardiac index was higher in the observation group than the control group,with statistically significant differences(P<0.05).Compared with the control group,the incidence of adverse pregnancy outcomes of the observation group(17.32%,22/127)was lower than that of the control group(28.35%,36/127),the incidence of adverse drug reactions of the observation group(2.

关 键 词：阿司匹林 拉贝洛尔 硝苯地平 子痫前期 妊娠结局 

分 类 号：R972.4[医药卫生—药品]