替加环素致不良反应的国内外文献分析  

Domestic and Foreign Literature of Adverse Drug Reactions Induced by Tigecycline

作　　者：周煊平 任俊丽 鲁汝淇 郑斌[2] 彭芳辰[2] ZHOU Xuanping;REN Junli;LU Ruqi;ZHENG Bin;PENG Fangchen(School of Pharmacy,Shanxi Medical University,Taiyuan 030607,China;Dept.of Pharmacy,Shanxi Provincial People’s Hospital,Taiyuan 030012,China)

机构地区：[1]山西医科大学药学院,太原030607 [2]山西省人民医院药学部,太原030012

出　　处：《中国医院用药评价与分析》2023年第2期241-244,共4页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：山西省卫生健康委科学研究课题计划项目(No.2022157)。

摘　　要：目的:探讨替加环素致药品不良反应(ADR)发生的特点及规律,为临床合理用药提供参考。方法:检索中国知网、维普数据库、万方数据库、PubMed、Web of Sciene和Embase等数据库中2005年1月至2022年8月发表的替加环素致ADR的个案报道,进行统计分析。结果:共纳入替加环素致ADR相关文献91篇,提取病例108例,其中男性68例,女性37例,性别不详3例;患者年龄主要为≥60岁(61例,占56.48%);患者原患疾病主要为肺部感染及腹腔感染。替加环素致ADR的发生时间为给药后10 min至给药后2.5个月,大多数ADR发生于给药后7 d内(72例,占66.67%)。替加环素所致ADR累及多个器官和(或)系统,共219例次,其中消化系统损害(105例次,占47.95%)最为常见,其次为血液系统损害(77例次,占35.16%)。大多数发生ADR的患者经停药或积极对症治疗后,1周内症状均有好转(68例,占62.96%)。结论:替加环素所致ADR可累及多个器官和(或)系统,临床表现多样,用药期间应加强替加环素致ADR的认识与监测,以减少或避免ADR的发生,保障患者安全用药。OBJECTIVE:To probe into the characteristics and regularity of adverse drug reactions(ADR)induced by tigecycline,so as to provide reference for clinical rational medication.METHODS:Case reports of ADR induced by tigecycline published from Jan.2005 to Aug.2022 were retrieved from CNKI,VIP,Wanfang Data,PubMed,Web of Sciene and Embase.RESULTS:Totally 91 studies related to ADR induced by tigecycline were enrolled,including 108 patients,including 68 males,37 females and 3 unknown gender;patients were mainly aged≥60 years(61 cases,56.48%);patients’primary diseases were mainly pulmonary infection and abdominal infection.The onset time of ADR induced by tigecycline ranged from 10 min after administration to 2.5 months after administration,with most ADR occurred within 7 d after administration(72 cases,66.67%).ADR induced by tigecycline had involved multiple organs and(or)systems,totally 219 case-times,with digestive system damage(105 case-times,47.95%)being the most common,followed by hematologic system damage(77 case-times,35.16%).Most patients who developed ADR were improved in symptoms within 1 week after drug withdrawal or receiving symptomatic treatment(68 cases,62.96%).CONCLUSIONS:ADR induced by tigecycline can involve multiple organs and/or systems,with diverse clinical manifestations,the awareness and monitoring of ADR induced by tigecycline should be strengthened during medication to reduce or avoid the occurrence of ADR,and to ensure safe medication for patients.

关 键 词：替加环素 药品不良反应 文献分析 

分 类 号：R978.1[医药卫生—药品]