自拟中药清热解毒方外敷治疗小儿输液外渗的临床效果及其对血管内皮功能的影响  

Clinical Effect of Self-Designed Qingre Jiedu Prescription(自拟中药清热解毒方)on Infantile Infusion Extravasation and Its Effect on Vascular Endothelial Function

作　　者：魏学燕[1] 底盼盼 贾红岩 李楠[1] WEI Xueyan;DI Panpan;JIA Hongyan;LI Nan(Shijiazhuang Maternal and Child Health Hospital,Shijiazhuang Hebei 050000,China)

机构地区：[1]石家庄市妇幼保健院,河北石家庄050000

出　　处：《中医药导报》2023年第2期106-110,共5页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：河北省卫健委2020年度医学科学研究课题项目(2020287)。

摘　　要：目的:探讨自拟中药清热解毒方外敷治疗小儿输液外渗的临床效果及对其血管内皮功能的影响。方法:将150例发生输液外渗所致局部皮肤组织损伤的患儿随机分为对照组和治疗组各75例。对照组患儿予常规50%硫酸镁湿敷治疗,治疗组患儿予自拟中药清热解毒方外敷治疗。比较两组患儿的治疗效果,包括治疗总有效率、红肿消退时间、疼痛消退时间、治愈时间等,同时检测并比较两组患儿治疗前后血管内皮细胞功能指标。结果:治疗组总有效率为97.33%(73/75),对照组总有效率为80.00%(60/75),治疗组优于对照组(P<0.05);治疗组患儿治疗后的红肿面积缩小率高于对照组(P<0.05),局部疼痛评分低于对照组(P<0.05),红肿消退时间、疼痛消退时间及治愈时间均短于对照组(P<0.05);两组患儿治疗后血清一氧化氮(NO)、内皮衍生超级化因子(EDHF)均较治疗前升高,血清内皮素(ET)水平均较治疗前降低,差异均有统计学意义(P<0.05);治疗组患儿治疗后血清NO、EDHF水平均高于对照组(P<0.05),血清ET水平均低于对照组(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:自拟中药清热解毒方外敷治疗小儿输液外渗所致局部组织损伤效果显著,其能更快且更明显地缓解患儿红肿、疼痛等临床症状,还能促进血管内皮细胞功能的恢复,而且无不良反应发生,值得临床推广应用。Objective:To explore the clinical effect of Self-Designed Qingre Jiedu Prescription on infusion extravasation in children and its effect on vascular endothelial function.Methods:Totally 150 children with local skin tissue injury caused by infusion were divided into treatment and control groups according to the principle of randomness,75 cases in each group.Patients were treated with conventional 50%magnesium sulfate wet compress in control group,and Self-Designed Qingre Jiedu Prescription in treatment group.The therapeutic effect was compared between the two groups,including the total effective rate,the regression time of redness,swelling and pain,the cure time,etc.At the same time,the changes of vascular endothelial cell function indexes were detected and compared between the two groups.Results:The total effective rate was 97.33%(73/75)in the treatment group and 80.00%(60/75)in the control group.The treatment group showed better clinical effect than control group,with significant difference(P<0.05).The treatment group showed higher reduction rate of redness and swelling area than control group(P<0.05),while lower local pain score than control group after treatment(P<0.05).The treatment group showed shorter redness and swelling regression time,pain regression time and cure time than control group(P<0.05).The levels of nitric oxide(NO)and endothelium derived hyperpolarizing factor(EDHF)increased in the two groups,while the endothelin(ET)decreased in the two groups after treatment,with significant difference(P<0.05).The treatment group showed higher levels of NO and EDHF than control group,while lower ET than control group after treatment,with significant difference(P<0.05).There was no significant difference in adverse reactions rate between the two groups(P>0.05).Conclusion:The external application of Self-Designed Qingre Jiedu Prescription has a significant effect in the treatment of local tissue injury caused by infusion extravasation in children.It can faster and more significantly alleviate the clinical sympt

关 键 词：静脉输液外渗 小儿 自拟中药清热解毒方 中药外敷 50%硫酸镁 血管内皮功能 

分 类 号：R248.4[医药卫生—中医临床基础]