短时受精结合早期补救单精子卵胞浆注射技术的新生儿结局  

Neonatal outcomes after short time insemination combined with early rescue intracytoplasmic sperm injection

作　　者：贺慧 黄博[1] 吴黎[1] 任新玲[1] 靳镭[1] 江亚萍 HE Hui;HUANG Bo;WU Li;REN Xinling;JIN Lei;JIANG Yaping(Reproductive Medicine Center,Tongji Hospital,Tongji Medicine College,Huazhong University of Science and Technology,Wuhan 430000,China)

机构地区：[1]华中科技大学同济医学院附属同济医院生殖中心,武汉430000

出　　处：《中国生育健康杂志》2023年第2期120-123,共4页Chinese Journal of Reproductive Health

基　　金：国家自然科学基金青年项目(81801443)。

摘　　要：目的观察短时受精结合早期补救单精子卵胞浆注射技术(Early-RICSI)的新生儿结局。方法回顾性分析2015年1月1日—2020年12月31日于华中科技大学同济医学院附属同济医院行常规体外受精(IVF)或Early-RICSI治疗并成功分娩活产儿患者的新生儿结局,包括性别比、孕周、出生体重、早产、早早产、低出生体重、极低出生体重、巨大儿。根据助孕方式,将患者分为IVF组和Early-RICSI组,其中IVF组共纳入单胎4927例,双胎2477例;Early-RICSI组纳入单胎369例,双胎161例。结果单胎活产儿中,两组剖宫产率、新生儿性别比、孕周、早产率、早早产率、出生体重、低体重率、极低出生体重率和巨大儿率差异均无统计学意义。而在双胎活产儿中,IVF组的平均出生体重显著低于Early-RICSI组[调整后平均差及95%可信区间:52.3(13.8~90.9)g,P=0.008],但是两组剖宫产率、新生儿性别比、孕周、早产率、早早产率、低体重率、极低出生体重率和巨大儿率在调整混杂因素后,差异均无统计学意义。结论短时受精结合早期补救单精子卵胞浆注射技术并未对患者的新生儿结局造成额外风险。Objective To investigate the neonatal outcomes after short time insemination combined with early rescue intracytoplasmic sperm injection(early-RICSI).Methods We retrospectively analyzed the neonatal outcomes of live births born by patients who underwent in vitro fertilization(IVF)or early-RICSI treatment between January 1,2015 and December 31,2020 in Tongji Hospital.The interested outcomes included sex ratio,gestational age,birthweight,rate of preterm birth,very preterm birth,low birthweight,very low birthweight and macrosomia.The patients were divided into IVF group or Early-RICSI group,according to the types of fertilization.Finally,4927 singletons and 2477 twins were included in IVF group,and 369 singletons and 161 twins were included in Early-RICSI group.Results Among singleton live births,no differences were observed between groups in cesarean rate,sex ratio,gestational age,rate of preterm birth and very preterm birth,birthweight,rate of low birthweight,very low birthweight and macrosomia.However,among twin live births,the mean birthweight in IVF group was significantly lower than early-RICSI group(adjusted mean difference and 95%confidence interval:52.3(13.8,90.9)g,P=0.008),while the cesarean rate,sex ratio,gestational age,rate of preterm birth and very preterm birth,rate of low birthweight,very low birthweight and macrosomia were comparable between groups after adjustment for confounding factors.Conclusion Short time insemination combined with early-RICSI treatment did not add extra risks to the neonatal outcomes.

关 键 词：早期补救卵胞浆内单精子注射(Early-RICSI) 短时受精 新生儿结局 

分 类 号：R71[医药卫生—妇产科学]