2型糖尿病合并肥胖患者肠道菌群分布与A-FABP、GLP-1水平的相关性  

Correlation between the distribution of intestinal flora and the levels of A-FABP and GLP-1 in patients with type 2 diabetes and obesity

作　　者：董业峰 葛仁美 宋格 DONG Yefeng;GE Renmei;SONG Ge(Department of Clinical Laboratory,Hai'an People's Hospital,Hai'an,Jiangsu,China,26600)

机构地区：[1]海安市人民医院检验科,江苏海安226600

出　　处：《分子诊断与治疗杂志》2023年第2期302-305,共4页Journal of Molecular Diagnostics and Therapy

基　　金：江苏省青年医学重点人才培养(QNRC2016833)。

摘　　要：目的 探讨2型糖尿病合并肥胖患者肠道菌群分布与脂肪型脂肪酸结合蛋白(A-FABP)、胰高血糖素样肽-1(GLP-1)水平的相关性。方法 拟选取2019年1月至2021年12月海安市人民医院就诊的103例2型糖尿病合并肥胖患者作为研究观察组,同期选择50名在本院行健康检查无糖尿病和肥胖者作为对照组,检测两组肠道菌群的分布与血清A-FABP、GLP-1水平,并分析2型糖尿病合并肥胖患者肠道菌群分布与血清A-FABP、GLP-1水平的相关性。结果 观察组肠球菌、肠杆菌检出水平显著高于对照组,差异有统计学意义(t=6.424,10.356,P<0.05),乳酸杆菌、双歧杆菌、梭杆菌、拟杆菌、类杆菌检出水平显著低于对照组,差异有统计学意义,差异有统计学意义(t=2.050,7.242,4.186,9.845,15.363,P<0.05);观察组A-FABP水平显著高于对照组,差异有统计学意义(t=10.298,P<0.05),GLP-1水平显著低于对照组,差异有统计学意义(t=27.819,P<0.05);肠球菌、肠杆菌与A-FABP水平呈正相关(P<0.05),乳酸杆菌、双歧杆菌、梭杆菌、拟杆菌、类杆菌与A-FABP水平呈负相关(P<0.05);肠球菌、肠杆菌与GLP-1水平呈负相关(P<0.05),乳酸杆菌、双歧杆菌、梭杆菌、拟杆菌、类杆菌与GLP-1水平呈正相关(P<0.05)。结论 2型糖尿病合并肥胖患者肠道菌群紊乱与A-FABP、GLP-1水平具有相关性,通过调节A-FABP、GLP-1水平对肠道细菌紊乱的治疗有一定指导作用。Objective To investigate the correlation between the distribution of intestinal flora and the levels of A-FABP and GLP-1 in type 2 diabetes mellitus patients with obesity. Methods A total of 103patients with type 2 diabetes mellitus complicated with obesity who were admitted to Hai’an People’s Hospital from January 2019 to December 2021 were selected as the study observation group,and 50 healthy people without diabetes and obesity who underwent health examination in our hospital during the same period were selected as the control group. The distribution of intestinal flora and serum A-FABP and GLP-1 levels in the two groups were detected,and the correlation between the distribution of intestinal flora and serum A-FABP and GLP-1 levels in patients with type 2 diabetes mellitus complicated with obesity was analyzed. Results The detection levels of Enterococcus and Enterobacter in the observation group were significantly higher than those in the control group(t=6.424,10.356,P<0.05),and the detection levels of Lactobacilli,Bifidobacteria,Fusobacterium,Bacteroides and Bacteroides were significantly lower than those in the control group(t=2.050,7.242,4.186,9.845,15.363,P<0.05). The levels of A-FABP in the observation group were significantly higher than that in the control group(t=10.298,P<0.05),and the levels of GLP-1 were significantly lower than that in the control group(t=27.819,P<0.05). Enterococcus and Enterobacter were positively correlated with A-FABP levels(P<0.05),while Lactobacillus,Bifidobacterium,Fusobacterium,Bacteroides and Bacteroides were negatively correlated with A-FABP level(P<0.05). Enterococcus and Enterobacter were negatively correlated with GLP-1 levels(P<0.05). Lactobacillus,Bifidobacterium,Fusobacterium,Bacteroides and Bacteroides were positively correlated with GLP-1 levels(P<0.05). Conclusion The intestinal flora disorder in patients with type 2 diabetes and obesity is correlated with the levels of A-FABP and GLP-1,and regulating the levels of A-FABP and GLP-1 can guide the treatment of

关 键 词：2型糖尿病 肥胖 肠道菌群分布 脂肪型脂肪酸结合蛋白 胰高血糖素样肽-1 

分 类 号：R587.1[医药卫生—内分泌] R589.2[医药卫生—内科学]