美洛昔康的临床应用研究现状  

State of clinical application of meloxicam

作　　者：李欣宇 黄鑫 LI Xinyu;HUANG Xin(Institute of Pharmaceutical Research,New Drug Screening Center,China Pharmaceutical University,Nanjing 210009,Jiangsu,China;Jiangsu Center for Pharmacodynamics Research and Evaluation,Nanjing 210009,Jiangsu,China;Key Laboratory of Drug Quality Control and Pharmacovigilance,Ministry of Education,China Pharmaceutical University,Nanjing 210009,Jiangsu,China)

机构地区：[1]中国药科大学药物科学研究院新药筛选中心,江苏南京210009 [2]江苏省药效研究与评价服务中心,江苏南京210009 [3]中国药科大学药物质量与安全预警教育部重点实验室,江苏南京210009

出　　处：《中国临床药理学与治疗学》2023年第2期189-197,共9页Chinese Journal of Clinical Pharmacology and Therapeutics

基　　金：国家自然科学基金(82174072)。

摘　　要：美洛昔康(meloxicam)是长效非甾体抗炎药,临床主要用于慢性骨关节炎的治疗和术后镇痛。近年研究发现该药物在抗肿瘤、改善阿尔兹海默病的认知障碍、动员造血干细胞等方面也有较大治疗潜力。本文综述了美洛昔康的药理机制研究,在胃肠道、肾脏、肝脏以及心血管方面的不良反应,从制剂的角度汇总了临床应用的各种形式,并总结了目前在临床与西药、中药分别联合用药的治疗策略。Meloxicam is a long-acting non-steroidal anti-inflammatory drug,which is mainly used in the treatment of chronic osteoarthritis and postoperative analgesia.Recent studies have found that the drug has great therapeutic potential in anti-tumor,improving cognitive impairment in Alzheimer’s disease,mobilizing hematopoietic stem cells and so on.This paper reviewed the pharmacological mechanism of meloxicam,the adverse reactions in gastrointestinal tract,kidney,liver and cardiovascular aspects,summarized various forms of clinical application from the perspective of preparation,and summarized the current clinical treatment strategy of combining with Western medicine and Chinese medicine respectively.

关 键 词：美洛昔康 不良反应 药理机制 联合用药 

分 类 号：R681[医药卫生—骨科学] R971[医药卫生—外科学]