HPV感染孕妇MCP-1和NOB1与TLR3及其诊断价值  

MCP-1,NOB1 and TLR3 in HPV-infected pregnant women and their diagnostic value

作　　者：毕媛 李黎[1] 彭敏[1] 王韵佳 龚晨 BI Yuan;LI Li;PENG Min;WANG Yun-jia;GONG Chen(Hubei maternal and Child Health Hospital,Wuhan Hubei 430000,China)

机构地区：[1]湖北省妇幼保健院产科,湖北武汉430000

出　　处：《中华医院感染学杂志》2023年第3期453-456,共4页Chinese Journal of Nosocomiology

基　　金：湖北省卫生健康委员会联合基金资助项目(WJ2019H298)。

摘　　要：目的 探讨人乳头状瘤病毒(HPV)感染孕妇单核细胞趋化蛋白-1(MCP-1)、酵母基因Noblp人类同源基因(NOB1)、Toll样受体3(TLR3)表达及其诊断价值。方法 选择2019年3月-2021年3月湖北省妇幼保健院孕期HPV感染的孕妇53例为研究组,另选同时期于医院孕检的53名健康孕妇为对照组。比较两组MCP-1、NOB1、TLR3表达情况,不同临床特征下MCP-1、NOB1、TLR3在孕期HPV感染中的表达情况。采用受试者工作特征(ROC)曲线分析MCP-1、NOB1、TLR3对孕期HPV感染的诊断价值。结果 感染组患者MCP-1、NOB1、TLR3水平高于对照组(P<0.05);孕晚期、妊娠次数>2次、血糖受损、吸烟的孕期HPV感染患者MCP-1、NOB1、TLR3水平较高(P<0.05);与MCP-1、NOB1、TLR3单项诊断相比,三项联合对孕期HPV感染的诊断价值较高(P<0.05)。结论 在孕期HPV感染患者中,MCP-1、NOB1、TLR3表达升高,联合预测孕期HPV感染的价值较高。OBJECTIVE To investigate the expression of monocyte chemoattractant protein-1(MCP-1),yeast gene noblp human homologous gene(NIN/RPN 12 binding protein 1,NOB1) and toll like receptor 3(TLR3) in human papillomavirus(HPV)infected pregnant women and their diagnostic value.METHODS Fifty-three patients with HPV infection during pregnancy in Hubei Maternal and Child Health Hospital from Mar.2019 to Mar.2021 were selected as the study group,and 53 healthy pregnant women who were examined at the hospital during the same period were selected as the control group.The expression of MCP-1,NOB1 and TLR3,as well as the expression of MCP-1,NOB1 and TLR3 in HPV infection during pregnancy under different clinical characteristics,were compared between two groups.The receiver operating characteristics(ROC) curve was used to analyze the diagnostic value of MCP-1,NOB1 and TLR3 for HPV infection during pregnancy.RESULTS The levels of MCP-1,NOB1 and TLR3 in the infected group were higher than those in the control group(P<0.05);The levels of MCP-1,NOB1 and TLR3 were higher in patients with HPV infection in the third trimester,with more than two pregnancies,with impaired blood glucose and with smoking(P<0.05).Compared with the single diagnosis of MCP-1,NOB1 and TLR3,the combined diagnosis of the three items was more valuable for the diagnosis of HPV infection during pregnancy(P<0.05).CONCLUSION Among patients with HPV infection during pregnancy,the expressions of MCP-1,NOB1 and TLR3 were elevated,and the combination of these indicators was of high value in predicting HPV infection during pregnancy.

关 键 词：单核细胞趋化蛋白-1 酵母基因Noblp人类同源基因 TOLL样受体3 孕期HPV感染 诊断价值 

分 类 号：R373[医药卫生—病原生物学]