补肾活血汤联合黄体酮治疗黄体功能不全性不孕临床研究  

Clinical Study on Bushen Huoxue Decoction Combined with Progesterone for Infertility Caused by Luteal Phase Defect

作　　者：陈虹宇[1] 姚奏英[2] 吴振波[1] CHEN Hongyu;YAO Zouying;WU Zhenbo

机构地区：[1]丽水市中心医院药学部,浙江丽水323000 [2]丽水市中心医院中医内科,浙江丽水323000

出　　处：《新中医》2023年第4期112-116,共5页New Chinese Medicine

摘　　要：目的:观察补肾活血汤联合黄体酮治疗黄体功能不全(LPD)性不孕的临床疗效。方法:选择LPD性不孕患者78例,按随机数字表法分为治疗组40例与对照组38例。对照组给予黄体酮胶囊治疗,治疗组在对照组的基础上给予补肾活血汤治疗。治疗3个月经周期后,比较2组临床疗效、中医证候积分、子宫内膜容受性及血清雌激素水平;并随访6个月,比较2组妊娠情况。结果:治疗组总有效率为87.50%,高于对照组68.42%,组间比较,差异有统计学意义(P<0.05)。治疗前,2组中医证候积分比较,差异无统计学意义(P>0.05);治疗后,2组中医证候积分均较治疗前降低(P<0.05),且治疗组中医证候积分低于对照组(P<0.05)。治疗前,2组子宫内膜厚度、子宫动脉搏动指数(PI)及阻力指数(RI)比较,差异无统计学意义(P>0.05)。治疗后,2组子宫内膜厚度较治疗前增加(P<0.05),PI、RI值较治疗前下降(P<0.05);且治疗组子宫内膜厚度大于对照组(P<0.05),PI、RI值低于对照组(P<0.05)。治疗前,2组血清孕酮(P)、雌二醇(E_(2))水平比较,差异无统计学意义(P>0.05);治疗后,2组P、E_(2)水平均较治疗前明显上升(P<0.05),且治疗组P、E_(2)水平高于对照组(P<0.05)。随访6个月,治疗组受孕率为42.5%,高于对照组15.79%,组间比较,差异有统计学意义(P<0.05)。结论:补肾活血汤加减联合黄体酮治疗LPD性不孕,有利于改善子宫内膜容受性及临床症状,提高受孕率,疗效优于单纯西药治疗。Objective:To observe the clinical effect of Bushen Huoxue Decoction on infertility caused by luteal phase defect(LPD).Methods:A total of 78 cases with infertility caused by LPD were selected and divided into the treatment group and the control group by random number table method,with 40 and 38 cases in each group respectively.The control group was given Progesterone Capsules,and the treatment group was treated with Bushen Huoxue Decoction based on the treatment of the control group.After treatment for 3 menstrual cycles,the clinical effects,traditional Chinese medicine(TCM)syndrome scores,endometrial receptivity and levels of serum estrogen in both groups were compared;the patients were followed up for 6 months and the pregnancy between the two groups were compared.Results:The total effective rate was 87.50% in the treatment group,higher than that of 68.42% in the control group,the difference being significant(P<0.05).Before treatment,there was no significant difference being found in the comparison of the TCM scores in the two groups(P>0.05);after treatment,the TCM scores in both groups were decreased when compared with those before treatment(P<0.05),and the TCM scores in the treatment group were lower than those in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparisons of endometrial thickness,and pulsatility index(PI)and resistance index(RI)of uterine artery between the two groups(P>0.05).After treatment,the endometrial thickness in both groups was increased when compared with that before treatment(P<0.05),and the PI and RI were decreased(P<0.05);the endometrial thickness in the treatment group was higher(P<0.05),and the levels of PI and RI were lower compared with those in the control group(P<0.05).Before treatment,there was no significant difference being found in the comparisons of levels of progesterone(P)and estradiol(E_(2))between the two groups(P>0.05);after treatment,the levels of P and E_(2)in both groups were significantly increased when compared

关 键 词：不孕症 黄体功能不全 补肾活血汤 黄体酮胶囊 子宫内膜容受性 雌激素 

分 类 号：R711.6[医药卫生—妇产科学]