加味茵陈蒿汤治疗湿热内蕴型肝硬化临床研究  

Clinical Study on Supplemented Virgate Wormwood Decoction in the Treatment of Cirrhosis with Syndrome of Dampness-Heat Internal Accumulation

作　　者：左璐 崔付超 ZUO Lu;CUI Fu-chao(Henan Infectious Disease Hospital,Zhengzhou,Henan,China,450052)

机构地区：[1]河南省传染病医院,河南郑州450052

出　　处：《河南中医》2023年第3期350-353,共4页Henan Traditional Chinese Medicine

基　　金：郑州市科技攻关计划项目(20120782)。

摘　　要：目的:观察加味茵陈蒿汤治疗湿热内蕴型肝硬化的临床疗效。方法:将60例湿热内蕴型肝硬化患者按照随机数字表法分为对照组和观察组,每组各30例。对照组给予当飞利肝宁胶囊口服,观察组在对照组治疗的基础上给予加味茵陈蒿汤。比较两组患者的临床疗效及治疗前后肝脏门静脉内径、脾脏厚度、脾静脉内径、肝功能指标[血清胆红素(total bilimbin,TBil)、丙氨酸氨基转移酶(alanine aminotransferase,ALT)、天门冬氨酸氨基转移酶(aspartate aminotransferase,AST)、白蛋白(albumin,ALB)]及肝纤维化指标[血清Ⅲ型前胶原蛋白(ProcollagenⅢ,PCⅢ)、层粘连蛋白(laminin,LN)、透明质酸(hyaluronic acid,HA)]变化情况。结果:观察组有效率为96.7%,对照组有效率为73.3%,两组患者有效率比较,差异具有统计学意义(P<0.05)。两组患者治疗后ALT、AST水平低于本组前,ALB、TBil水平高于本组前,且治疗后组间比较,差异均有统计学意义(P<0.05)。两组患者治疗后PCⅢ、LN、HA指标低于本组治疗前,且治疗后观察组低于对照组,差异具有统计学意义(P<0.05)。两组患者治疗后门静脉内径、脾静脉内径、脾脏厚度低于本组治疗前,且治疗后观察组低于对照组,差异具有统计学意义(P<0.05)。结论:加味茵陈蒿汤治疗湿热内蕴型肝硬化,可改善患者临床症状及肝功能、肝纤维化指标。Objective:To observe the clinical efficacy of Supplemented Virgate Wormwood Decoction combined with Entecavir Tablets on cirrhosis with syndrome of dampness-heat internal accumulation.Methods:A total of 60 patients with cirrhosis with syndrome of dampness-heat internal accumulation were randomly divided into the control group and the observation group,with 30 cases in each group.The control group was given Dangfei Liganning Capsule orally,while the observation group was given Supplemented Virgate Wormwood Decoction on the basis of the treatment of the control group.The clinical efficacy,the changes of the diameter of the hepatic portal vein,the thickness of the spleen,the diameter of the splenic vein,liver function indexes [including serum bilirubin(TBil),alanine aminotransferase(ALT),aspartate aminotransferase(AST),albumin(ALB)] and liver fibrosis indexes [including serum procollagen Ⅲ(PC Ⅲ),laminin(LN),hyaluronic acid(HA)] of the two groups before and after treatment were compared.Results:The effective rate was 96.7% in the observation group and 73.3% in the control group.The difference between the two groups was statistically significant(P<0.05).After treatment,the levels of ALT and AST in the two groups were lower than those of the same group before the treatment,while the levels of ALB and TBil were higher than those before the treatment,and all the differences between the two groups were statistically significant(P<0.05).After treatment,the indexes of PC Ⅲ,LN and HA in the two groups were lower than those of the same groupbefore treatment,and the above indexes of the observation group were lower than those of the control group,and all the differences were statistically significant(P<0.05).The diameter of the portal vein,the diameter of the splenic vein and the thickness of the spleen in the two groups were lower than those of the same group before the treatment,and the above indexes of the observation group were lower than those of the control group,and all the differences were statistically significa

关 键 词：肝硬化 湿热内蕴证 加味茵陈蒿汤 当飞利肝宁胶囊 中西医结合疗法 《伤寒论》 张仲景 

分 类 号：R259.752[医药卫生—中西医结合]