Size-dependent cellular uptake and sustained drug release of PLGA particles  

作　　者：Rui Sun Xia Liu Yu Zhang Qian Li Ying Zhu Chunhai Fan 

机构地区：[1]Division of Physical Biology,CAS Key Laboratory of Interfacial Physics and Technology,Shanghai Institute of Applied Physics,Chinese Academy of Sciences,Shanghai 201800,China [2]The Interdisciplinary Research Center,Shanghai Synchrotron Radiation Facility,Zhangjiang Laboratory,Shanghai Advanced Research Institute,Chinese Academy of Sciences,Shanghai 201210,China [3]University of Chinese Academy of Sciences,Beijing 100049,China [4]School of Chemistry and Chemical Engineering,Frontiers Science Center for Transformative Molecules and National Center for Translational Medicine,Shanghai Jiao Tong University,Shanghai 200240,China

出　　处：《Particuology》2023年第2期1-7,共7页颗粒学报（英文版）

基　　金：supported by the National Natural Science Foundation of China (No.22022410,No.82050005,No.12105352);the Youth Innovation Promotion Association of Chinese Academy of Sciences (No.2012205,No.2016236).

摘　　要：Poly(lactic-co-glycolic)acid(PLGA)particles have become a commonly used drug delivery strategy in the pharmaceutical industry.In this work,we aim to investigate the size-dependent cellular internalization of PLGA particles and its effects on sustained drug release.We prepared three different-sized particles using PLGA(200,500 and 2000 nm)ranging from submicrometer to micrometer.Dexamethasone(DEX)with excellent anti-inflammatory properties was used as a model drug to prepare DEX-loaded PLGA particles(DPs).We comprehensively investigated the encapsulation efficiency,cellular uptake and in vitro drug release profile.Pharmacodynamic assessment revealed that,in the lipopolysaccharide(LPS)-induced RAW 264.7 cells model,500 nm DPs showed sustained anti-inflammatory efficacy.This work provides important information for designing PLGA-based drug delivery systems for biomedical applications.

关 键 词：DEX-loaded PLGA particles(DPs) Sustained release Anti-inflammatory efficacy 

分 类 号：R31[医药卫生—基础医学]