Kinetic study of complicated anti-solvent and cooling crystallization of disodium 5′-ribonucleotide  

作　　者：Wang Zhao Binghui Li Shiyuan Liu Yuehua Deng Rui Zhang Yanbin Jiang 

机构地区：[1]Guangdong Provincial Key Lab of Green Chemical Product Technology,School of Chemistry and Chemical Engineering,South China University of Technology,Guangzhou,510640,China [2]Zhuhai Institute of Modern Industrial Innovation,South China University of Technology,Zhuhai,519175,China [3]School of Chemical Engineering,Guangdong University of Petrochemical Technology,Maoming,525000,China

出　　处：《Particuology》2023年第2期103-112,共10页颗粒学报（英文版）

基　　金：Financial supports from the National Natural Science Foundation of China (Nos.22178121 and 21908254)are greatly appreciated.

摘　　要：Disodium 5′-ribonucleotide,which is composed of disodium 5′-inosine(IMP)and disodium 5′-guanosine(GMP),is an important food additive.The lack of kinetic studies of it causes a lack of clarity in understanding the complicated multi-solute crystallization of IMP+GMP in ethanol-water.In this work,process analytical technology tools were used to obtain the thermodynamics and kinetic data from the experiments,the kinetic parameters of anti-solvent and cooling crystallization were investigated.The crystal form of IMP+GMP mixed crystal was determined,which was consistent with the IMP whether crystallized from pure water or ethanol-water.The effects of different anti-solvent addition rates and cooling rates on the metastable zone widths were studied,and the opposite effect on metastable zone width was found.The modified exponential empirical function was developed to correlate nucleation and growth kinetic equations under different conditions.The kinetic data were well fitted with adjusted correlation coefficient(adj-R^(2)>0.7),which is sufficient to provide a valid reference for process design and control.

关 键 词：Disodium 5′-ribonucleotide Multi-solute crystallization Nucleation and growth kinetics Process analytical technology tools Metastable zone widthMixed crystal 

分 类 号：TG1[金属学及工艺—金属学]