熔体结晶应用于药物多晶型研究进展  

Recent advances of melt crystallization in pharmaceutical polymorphism

作　　者：李淑婷 李澳 刘彬彬 陆明[1] LI Shuting;LI Ao;LIU Binbin;LU Ming(School of Pharmaceutical Sciences,Sun Yat-sen University,Guangzhou 510006,China)

机构地区：[1]中山大学药学院,广州510006

出　　处：《化学工业与工程》2023年第1期41-52,共12页Chemical Industry and Engineering

摘　　要：综述了熔体结晶应用于药物多晶型领域的研究进展,包括常规熔体结晶、聚合物诱导熔体结晶、纳米限域熔体结晶和熔体微液滴培养单晶技术,以期助力药物多晶型和固态化学研究。Here we reviewed recent advances of melt crystallization in pharmaceutical polymorphism,including routine melt crystallization,polymer-assistant crystallization,nanoconfinement crystallization and melt microdroplet strategy for single-crystal cultivation.This work aims to promote the research in drug polymorphism and solid-state chemistry.

关 键 词：熔体结晶 药物多晶型 聚合物诱导结晶 纳米限域结晶 熔体微液滴培养单晶技术 

分 类 号：R9[医药卫生—药学]