经皮穴位电刺激联合耳穴贴压对性早熟女童性激素水平及性腺发育的影响  

Effect of transcutaneous electrical acupoint stimulation combined with auricular acupressure on sexual hormone level and gonadal development in girls with precocious puberty

作　　者：刘莉莉[1] 万乃君[2] 孙慧慧[2] 张亚妹[2] 吕艳伟[3] LIU Li-li;WAN Nai-jun;SUN Hui-hui;ZHANG Ya-mei;LÜYan-wei(Department of Acupuncture and Moxibustion,Beijing Jishuitan Hospital,Beijing 100035,China;Department of Pediatrics,Beijing Jishuitan Hospital,Beijing 100035,China;Clinical Epidemiology Research Centre,Beijing Jishuitan Hospital,Beijing 100035,China)

机构地区：[1]北京积水潭医院针灸科,北京100035 [2]北京积水潭医院儿内科,北京100035 [3]北京积水潭医院临床流行病学研究室,北京100035

出　　处：《针刺研究》2023年第2期199-203,210,共6页Acupuncture Research

基　　金：北京市属医院科研培育计划项目(No.PZ2019004)。

摘　　要：目的:探讨经皮穴位电刺激(TEAS)联合耳穴贴压对性早熟女童血清性激素水平、卵巢、卵泡及子宫发育的影响。方法:将性早熟女童随机分为对照组28例和治疗组27例。对照组和治疗组均接受健康生活方式干预12周。此外,治疗组接受TEAS治疗,每次20 min,每周2次,并配合双侧耳穴贴压,共治疗12周。分别于治疗前后检测两组性早熟女童血清促黄体生成素(LH)、卵泡刺激素(FSH)、雌二醇(E2)水平,测量其卵巢容积、最大卵泡直径、子宫容积,并对治疗安全性进行评价。结果:与治疗前比较,对照组治疗后血清LH、FSH含量升高(P<0.05),卵巢容积、最大卵泡直径增大(P<0.05);治疗组治疗后血清FSH、E2含量降低(P<0.05),最大卵泡直径缩小(P<0.05)。治疗后与对照组比较,治疗组血清LH、FSH、E2含量均降低(P<0.05),卵巢容积、最大卵泡直径均缩小(P<0.05)。结论:TEAS联合耳穴贴压可有效降低性早熟女童的性激素水平,改善其卵巢和卵泡发育,减缓性腺发育速度,且安全性高。Objective To explore the effect of transcutaneous electrical acupoint stimulation(TEAS)combined with auricular acupressure on serum sexual hormone level,and the ovarian,follicular and uterine development in the girls with precocious puberty.Methods Sixty girls with precocious puberty were randomly divided into a control group(30 cases,2 cases dropped off)and a treatment group(30 cases,3 cases dropped off).In both the control group and the treatment group,the healthy life-style intervention was provided for 12 weeks.Besides,in the treatment group,TEAS was delivered for 20 minutes each time,twice a week;and bilateral auricular acupressure was combined.The duration of treatment was 12 weeks.The levels of serum luteinizing hormone(LH),follicle stimulating hormone(FSH)and estradiol(E2),as well as ovarian volume,maximum follicular diameter and uterine volume before and after treatment were detected,and the safety was evaluated separately.Results Compared with before treatment,the contents of serum LH and FSH were increased(P<0.05),and the ovarian volume and the maximum follicle diameter were increased(P<0.05)in the control group after treatment;the contents of serum FSH and E2were decresed(P<0.05),and the maximum follicular diameter was reduced significantly(P<0.05)in the treatment group after treatment.Compared with the control group,the contents of serum LH,FSH and E2were decreased(P<0.05),while the ovarian volume and the maximum follicle diameter were decreased(P<0.05)in the treatment group after treatment.Conclusion TEAS combined with auricular acupressure can effectively decrease the level of sex hormone,improve the ovarian and uterine development and retard the gonadal development.Such combined therapy is of high safety and conductive to regulating the development for the girls with precocious puberty.

关 键 词：经皮穴位电刺激 耳穴贴压 性早熟 女童 随机对照试验 

分 类 号：R245.97[医药卫生—针灸推拿学]