武汉市男男性行为人群艾滋病非职业暴露后预防用药需求及影响因素  

Demand and influencing factors of non-occupational post-exposure prophylaxis for AIDS among men who have sex with men in Wuhan

作　　者：刘玉新 孔德广[3] 王夏[3] 马红飞 闫晗 罗纹 陈菥 LIU Yu-xin;KONG De-guang;WANG Xia;MA Hong-fei;YAN Han;LUO Wen;CHEN Xi(Wuhan Hanyang District Center for Disease Control and Prevention,Wuhan,Hubei 430050,China;Wuhan Field Epidemiology Training Program,Wuhan,Hubei 430015,China;Wuhan Center For Disease Control and Prevention,Wuhan,Hubei 430015,China)

机构地区：[1]武汉市汉阳区疾病预防控制中心,湖北武汉430050 [2]武汉现场流行病学培训项目,湖北武汉430015 [3]武汉市疾病预防控制中心,湖北武汉430015

出　　处：《中国热带医学》2023年第2期167-172,共6页China Tropical Medicine

摘　　要：目的了解武汉市男男性行为(men who have sex with men,MSM)人群艾滋病非职业暴露后预防(non-occupational post-exposure prophylaxis,nPEP)用药需求及相关影响因素,为后续MSM人群干预政策的制定提供科学依据。方法在武汉市社会组织的协助下采用滚雪球方法招募MSM开展网络问卷调查,收集人口学、艾滋病相关知识、高危行为及对nPEP用药需求等信息。采用χ^(2)检验和非条件Logistic回归分析nPEP用药需求的相关影响因素。结果本次研究共纳入308名有效调查对象,以18~29岁为主(78.57%,242/308),自我报告性取向以同性恋为主(82.47%,254/308),艾滋病知识知晓率较高(89.29%,275/308)。调查对象中,35.06%(108/308)不知道武汉市MSM人群感染艾滋病疫情情况;55.19%(170/308)最近半年同性性伴数在2个及以上;90.91%(280/308)在参加本次调查之前已听说过nPEP,告知nPEP药物保护效果后,需要nPEP者占59.42%(183/308)。在发生HIV暴露后,愿意花钱购买nPEP药物者占73.38%(226/308),既知有副作用,愿意服用nPEP药物者占88.64%(273/308)。Logistic回归分析结果提示,最近半年有2个及以上同性性伴(OR=2.121,95%CI:1.329~3.386)、接受过同伴教育(OR=1.740,95%CI:1.088~2.781)者nPEP用药需求分别高于最近半年有1个同性性伴、未接受过同伴教育者。结论武汉市MSM人群对nPEP药物有较大需求,同伴教育是开展nPEP宣传和推广的重要途径;同时应继续加强警示性宣传教育和行为干预工作,以减少MSM危险性行为降低其HIV新发感染。Objective To investigate the drug demand and related influencing factors of AIDS non-occupational postexposure prophylaxis(nPEP)among men who have sex with men(MSM)in Wuhan,and to provide a scientific basis for the development of subsequent intervention policies for MSM.Methods With the assistance of social organizations in Wuhan,MSM was recruited by the snowball method to carry out an online questionnaire survey to collect information on demographics,AIDS-related knowledge,high-risk behaviors,and the need for nPEP medication.Theχ^(2)test and unconditional Logistic regression were used to analyze the related factors of the demand for nPEP medication.Results A total of 308 valid subjects were included in this study,with predominantly 18-29 years old(78.57%,242/308).The self-reported sexual orientation was mainly homosexuality(82.47%,254/308),and the awareness rate of AIDS knowledge was high(89.29%,275/308).Among the survey respondents,35.06%(108/308)did not know the situation of HIV infection among MSM population in Wuhan;55.19%(170/308)had two or more same-sex sexual partners in the last six months;90.91%(280/308)had heard of nPEP before participating in this survey.After passing nPEP and informing the protective effect of nPEP,59.42%(183/308)of them needed nPEP.After HIV exposure,73.38%(226/308)were willing to spend money to buy nPEP drugs,and 88.64%(273/308)were willing to take nPEP drugs because of the known side effects.Logistic regression analysis showed that in the last six months,the needs for taking nPEP medication in those who had 2 or more same-sex sexual partners(OR=2.121,95%CI:1.329-3.386)and who had received peer education(OR=1.740,95%CI:1.088-2.781)were higher than those of those who had a same-sex sexual partner in the last six months and who had not received peer education.Conclusions The MSM population in Wuhan has a great demand for nPEP drugs,and peer education is an important way to carry out nPEP publicity and promotion.At the same time,we should continue to strengthen warning publicity and

关 键 词：艾滋病 男男性行为者 非职业暴露后预防 影响因素 

分 类 号：R512[医药卫生—内科学]