代谢组学在儿童社区获得性肺炎的研究现状  

Current status of metabolomics in pediatric community-acquired pneumonia

作　　者：刘淑琼 余阗 曾赛珍 陈玲玲 吴佩[1] 黄倩[1] Liu Shuqiong;Yu Tian;Zeng Saizhen;Chen Lingling;Wu Pei;Huang Qian(Department of Pediatrics,the First Affiliated Hospital of Hunan Normal University/Hunan Provincial People′s Hospital,Changsha 410005,China;Changsha Hospital for Maternal and Child Health Care,Changsha 410007,China)

机构地区：[1]湖南师范大学附属第一医院(湖南省人民医院)儿童医学中心,长沙410005 [2]长沙市妇幼保健院,410007

出　　处：《中国小儿急救医学》2023年第2期126-130,共5页Chinese Pediatric Emergency Medicine

基　　金：长沙市科技计划项目(kq1901053);湖南省人民医院仁术基金(RS201709);湖南省儿童呼吸疾病重点实验室项目(2019TP1043)。

摘　　要：社区获得性肺炎(community acquired pneumonia,CAP)是5岁以下儿童死亡的主要原因之一。早期识别并明确其严重程度,采取适当的治疗措施可以提高生存率,但现有应用于诊断CAP的实验室指标存在局限性。因此,仍然需要寻找新的、特异性高的生物学标志物能够在疾病恶化之前明确病原并能预测疾病严重程度,为制定更有效的治疗措施提供依据。代谢组学通过对生物样品中代谢产物变化的定性定量分析,为寻找生物学标志物和发病机制提供了新的途径。本文对代谢组学在儿童CAP中的最新研究进展进行综述,为儿童CAP的早期诊断及治疗提供新的思路。Community-acquired pneumonia(CAP)is one of the leading causes of death in children under 5 years of age.Early identification and clarification of its severity and appropriate therapeutic measures can improve survival,but there are limitations in the existing laboratory indices applied to diagnose CAP.Therefore,it is still necessary to find new and highly specific biomarkers that can identify the etiology and predict the severity of the disease before it worsens in children,and provides a basis for more effective therapeutic measures.Metabolomics provides a new way to search for biomarkers and pathogenesis through qualitative and quantitative analysis of metabolite changes in biological samples.This review summarized the latest research progress on metabolomics in childhood CAP,hoping to provide ideas for the early diagnosis and treatment of childhood CAP.

关 键 词：社区获得性肺炎 代谢组学 儿童 

分 类 号：R725.6[医药卫生—儿科]