链霉蛋白酶联合不同剂量西甲硅油对电子胃镜检查中视野清晰度及麻醉药用量的影响  

Effects of Streptomycin Combined with Different Doses of Simethicone Oil on Visual Field Clarity and Anesthetic Dosage in Electronic Gastroscopy

作　　者：吴小配 于智慧 房晓文 WU Xiao-pei;YU ZHi-hui;FANG Xiao-wen(Endoscopic Center,Shandong Provincial Third Hospital,Jinan Shandong 250000)

机构地区：[1]山东省立第三医院内镜中心,山东济南250000

出　　处：《医学临床研究》2023年第2期245-247,251,共4页Journal of Clinical Research

摘　　要：【目的】探讨不同剂量西甲硅油联合链霉蛋白酶对电子胃镜检查中视野清晰度及麻醉药用量的影响。【方法】前瞻性选取2020年8月至2021年8月于本院行电子胃镜检查的231例患者,采用随机数字表法将其分为小剂量组(200 mg西甲硅油)、中剂量组(400 mg西甲硅油)与大剂量组(600 mg西甲硅油),每组77例。比较三组患者胃镜视野清晰度及优良率、丙泊酚用量、胃镜检查总时间、胃镜检查期间不良反应发生率(血氧饱和度下降、心率减缓、呛咳、呕吐、头晕),并于给药前(T_(0))、诱导给药即刻(T_(1))、入镜时(T_(2))、检查开始3 min(T_(3))、检查结束(T_(4))测定三组患者血流动力学指标[心率(HR)、平均动脉压(MAP)]。【结果】三组患者视野清晰度优良率比较,大剂量组>中剂量组>小剂量组,差异有统计学意义(P<0.05)。三组丙泊酚用量及胃镜检查总时间比较,大剂量组<中剂量组<小剂量组,差异有统计学意义(P<0.05)。三组患者不同时点HR、MAP比较,差异无统计学意义(P>0.05)。三组不良反应发生率比较,中剂量组<小剂量组<大剂量组,差异有统计学意义(P<0.05)。【结论】链霉蛋白酶联合400 mg西甲硅油较为适宜应用于电子胃镜检查中,既可提升电子胃镜视野清晰度,又可减轻患者不良反应,值得临床借鉴。【Objective】To investigate the effects of different doses of silicone oil and streptomycin on the visual field clarity and anesthetic dosage in electronic gastroscopy.【Methods】A total of 231 patients who underwent electronic gastroscopy in our hospital from August 2020 to August 2021 were prospectively selected.They were randomly divided into low dose group(200 mg of silicone oil),medium dose group(400 mg of silicone oil)and high dose group(600 mg of silicone oil),with 77 patients in each group.The patients in the three groups were compared in terms of gastroscope visual field clarity,excellent and good rate,anesthetic dosage,total time of gastroscope examination and adverse reaction rate during gastroscope examination(decreased blood oxygen saturation,slow heart rate,choking,vomiting,dizziness).The hemodynamic indexes[heart rate(HR),mean arterial pressure(MAP)]of the three groups of patients before administration(T_(0)),immediately after induction administration(T_(1)),at the time of endoscopy(T_(2)),at the beginning of examination(T_(3))and at the end of the examination(T_(4))were measured.【Results】There were significant differences in the excellent and good rate of visual field definition among the three groups:the high-dose group>medium-dose group>low-dose group;And the differences were statistically significant(P<0.05).The anesthesia dosage and total time of gastroscopy in the three groups were high-dose group<medium-dose group<low-dose group.The differences were significantly different(P<0.05).There was no significant difference in HR and MAP between the three groups at different time points(P>0.05).The incidence of adverse reactions among the three groups was statistically significant as the middle-dose group<low-dose group<high-dose group.【Conclusion】Streptomyces protease(pronase)combined with 400 mg of silicone oil is more suitable for use in electronic gastroscopy,which can not only improve the visual field of electronic gastroscopy,but also reduce the adverse reactions of patients,which

关 键 词：胃镜检查 硅油类/投药和剂量 链霉蛋白酶/投药和剂量 麻醉药 

分 类 号：R446.112[医药卫生—诊断学]