静注人免疫球蛋白对新生儿乙肝核心抗体的影响  

Effect of Intravenous Immunoglobulin on Hepatitis B Core Antibody in Neonates

作　　者：杨淋 杨广[1] 邓涛 Yang Lin;Yang Guang;Deng Tao(Panzhihua Maternal and Child Health Hospital,Sichuan Panzhihua 617000,China)

机构地区：[1]攀枝花市妇幼保健院,四川攀枝花617000

出　　处：《儿科药学杂志》2023年第3期48-50,共3页Journal of Pediatric Pharmacy

摘　　要：目的:探讨新生儿使用静注人免疫球蛋白(IVIG)后乙肝核心抗体(HBcAb)的变化。方法:采用回顾性研究方法,收集我院2019-2020年使用IVIG的住院新生儿病历,分析使用IVIG前后患儿HBcAb的变化。结果:共收集43例患儿,其中5例使用IVIG前后HBcAb均呈阳性,10例使用IVIG前后HBcAb均呈阴性,18例使用IVIG后HBcAb由阴性转为阳性,10例使用IVIG后因未进行乙肝5项复测未知HBcAb的变化。结论:输注IVIG会引起新生儿HBcAb水平升高,提示对输注IVIG的患儿进行抗体被动转移的排除具有重要意义。Objective:To investigate the changes of hepatitis B core antibody(HBcAb)in newborns after intravenous immunoglobulin(IVIG).Methods:Retrospective research method was conducted in this study to collect medical records of newborns who had IVIG in our hospital from 2019 to 2020,and the changes of HBcAb before and after using IVIG were compared.Results:Among 43 hospitalized children treated with IVIG,5 children were HBcAb positive before IVIG treatment;HBcAb was still negative in 10 children after IVIG treatment;HBcAb was positive in 18 children after IVIG;10 children were not retested for hepatitis B after IVIG,so the changes of HBcAb were unknown.Conclusion:Infusion of IVIG can increase the level of HBcAb in neonates,which suggests that it is of great significance to eliminate passive transfer of antibodies in neonates with IVIG.

关 键 词：静注人免疫球蛋白 乙肝核心抗体 抗体被动转移 

分 类 号：R722.1[医药卫生—儿科]