基于肠道菌群与骨骼肌关系探讨从脾论治重症肌无力的作用机制  

Mechanism of Treating Myasthenia Gravis from Spleen Under Guidance of Intestinal Flora and Skeletal

作　　者：陈茉 赵欢[2] 文颖娟[2] 王江[2] 柏鲁宁[2] CHEN Mo;ZHAO Huan;WEN Yingjuan;WANG Jiang;BAI Luning(Weinan Central Hospital affiliated to Shaanxi University of Chinese Medicine,Shaanxi Weinan 714000,China;Shaanxi University of Chinese Medicine,Shaanxi Xianyang 712046,China)

机构地区：[1]陕西中医药大学附属渭南市中心医院,陕西渭南714000 [2]陕西中医药大学,陕西咸阳712046

出　　处：《陕西中医药大学学报》2023年第2期70-76,共7页Journal of Shaanxi University of Chinese Medicine

基　　金：国家自然科学基金项目(81202642);第四批全国中医(临床、基础)优秀人才研修项目(国中医药人教发[2017]24号);陕西省科技厅项目(2023-YBSF-005);2021年度陕西中医药大学校级科研课题(1451006)

摘　　要：重症肌无力(myasthenia gravis,MG)是一种自身免疫性疾病,其发病机制尚未完全阐明。中医学认为,脾胃虚弱,浊邪堆积为重症肌无力发病的病因病机,脾与重症肌无力的发病关系密切。肠道菌群及其代谢产物可以调节MG发病机制,调节肠道菌群干预骨骼肌运动作为研究热点,近年来受到学者们的广泛关注。基于此提出从肠肌轴学说出发,明确菌群失衡对重症肌无力的干预机制,进一步证实肠肌轴学说的存在,以及应用中医藏象学说理论,探究从脾调控肠肌轴干预重症肌无力治疗的可行性,为临床用药提供一定的思路与方法。Myasthenia gravis is an autoimmune disease,and its pathogenesis has not been fully clarified.As a research hotspot,regulating intestinal microflora to interfere with skeletal muscle movement has been widely concerned by scholars in recent years.Traditional Chinese medicine believes that weakness of spleen and stomach and accumulation of turbid pathogens are the etiology and pathogenesis of myasthenia gravis.The spleen is the source of Qi and blood biochemistry,which is used to transport and purify blood,control the limbs,transfuse body fluid,and nourish the tendons.It is closely related to the onset of myasthenia gravis.Based on this,it is proposed to clarify the intervention mechanism of bacterial imbalance on myasthenia gravis from the intestinal muscle axis theory,further confirm the existence of the intestinal muscle axis theory,and explore the feasibility of the intervention of myasthenia gravis treatment from the spleen to regulate the intestinal muscle axis by applying the theory of visceral signs in traditional Chinese medicine.To provide certain ideas and methods for clinical medication.

关 键 词：肠肌轴 骨骼肌 肠道菌群 重症肌无力 脾 

分 类 号：R746.1[医药卫生—神经病学与精神病学]