生物金属有机框架在药物递送系统中的研究进展  

Research progress of bio-metal organic frameworks in drug delivery system

作　　者：于佳玉 蔺泽之 曹威 张建军[1] 魏元锋[2] 高缘[2] 钱帅[2] YU Jiayu;LIN Zezhi;CAO Wei;ZHANG Jianjun;WEI Yuanfeng;GAO Yuan;QIAN Shuai(School of Pharmacy,China Pharmaceutical University,Nanjing 211198;School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 211198,China)

机构地区：[1]中国药科大学药学院,南京211198 [2]中国药科大学中药学院,南京211198

出　　处：《中国药科大学学报》2023年第1期23-33,共11页Journal of China Pharmaceutical University

基　　金：国家自然科学基金资助项目(No.8207141408,No.82204636);江苏省自然科学基金资助项目(No.SBK2020042291);中国博士后科学基金资助项目(No.2020M671665)。

摘　　要：近年来,以生物相容性的配体合成的生物金属有机框架(bio-metal organic frameworks,Bio-MOFs)因其巨大的比表面积及孔隙率,丰富的主客体分子间相互作用,及良好的生物相容性特征,成为了一种极具潜力的药物递送载体,受到了广泛研究。本文概述了Bio-MOFs的设计方法包括结构和毒性因素,概述包括点击化学在内的多种载药方法,重点介绍了BioMOFs用于肺部给药系统、改善药物药学性质、缓控释递药系统、刺激响应及靶向给药系统等方面的最新研究进展,并总结了限制Bio-MOFs用于实际药物制剂临床研究或上市制剂当中的发展瓶颈和未来发展方向,为推动Bio-MOFs在药物递送系统中的应用提供理论参考。In recent years,bio-metal organic frameworks(Bio-MOFs)synthesized with biocompatible ligands have been widely investigated as a potential drug delivery carrier due to their large specific surface area and porosity,rich host-guest intermolecular interactions,and good biocompatibility.In this review,we summarized the design methods of Bio-MOFs including structural and toxic factors,as well as a variety of drug loading methods including click chemistry,with particular focus on recent research advances in Bio-MOFs for pulmonary drug delivery systems,improving pharmaceutical properties of drugs,sustained and controlled drug release,stimulation response and targeted drug delivery systems.Finally,we summarized the bottlenecks that constrain the development of Bio-MOFs in clinical studies of actual pharmaceutical formulations and their future directions for approved formulations,aiming to provide some theoretical reference for promoting the application of Bio-MOFs in drug delivery systems.

关 键 词：金属有机框架 生物相容性 合成 载药 药物递送系统 

分 类 号：R943[医药卫生—药剂学]