白蛋白冠的构建及其在药物制剂研究中的应用  

Construction of albumin corona and its application in pharmaceutical preparation

作　　者：杨清麟 韩雷强 刘永军 张娜 YANG Qinglin;HAN Leiqiang;LIU Yongjun;ZHANG Na(Ministry of Education Key Laboratory of Chemical Biology,School of Pharmaceutical Sciences,Shandong University,Ji'nan 250012;Department of Clinical Pharmacy,the Second Hospital of Shandong University,Ji'nan 250033,China)

机构地区：[1]山东大学药学院天然产物化学生物学教育部重点实验室,济南250012 [2]山东大学第二医院临床药学科,济南250033

出　　处：《中国药科大学学报》2023年第1期49-55,共7页Journal of China Pharmaceutical University

基　　金：国家自然科学基金资助项目(No.81974498,No.82003704)。

摘　　要：蛋白冠(protein corona)是纳米颗粒与血浆蛋白之间发生非特异性相互作用后在表面吸附的蛋白层。近年来研究表明,在纳米颗粒表面修饰特定血浆蛋白质构建蛋白冠具有延长纳米颗粒血液半衰期、促进纳米颗粒靶向递送等作用,引起载药系统研究的广泛关注。其中,以血液中含量最为丰富的蛋白质白蛋白构建白蛋白冠(albumin corona)研究最为广泛。基于此,本文系统性总结了构建白蛋白冠的方法及其在药物制剂研究中的应用,以期为药物制备过程中构建白蛋白冠提供参考。Protein corona is a protein layer that adsorbs on the surface after nonspecific interactions between nanoparticles and plasma proteins.In recent years,studies have shown that modification of specific plasma proteins on the surface of nanoparticles to construct protein corona can prolong the blood half-life of nanoparticles and promote the targeted delivery of nanoparticles,which has attracted widespread attention to the study of drugcarrying systems,among which,albumin corona,the most abundant protein in blood,is the most widely studied.Based on the above,this paper systematically summarized the method of constructing albumin corona and its application in the research on pharmaceutical preparations,in order to provide reference for the construction of albumin corona in the process of drug preparation.

关 键 词：蛋白冠 白蛋白冠 药物递送 表面修饰 特异性吸附白蛋白 

分 类 号：R943[医药卫生—药剂学]