青钱柳中一个新的酯苷类化合物  

A new ester glycoside compound from Cyclocarya paliurus

作　　者：方泗杨 张兴贵 叶宇 王珂清[3] 姚志仁 黄亚萍 张健[2] 秦艳华[3] 殷志琦 FANG Siyang;ZHANG Xinggui;YE Yu;WANG Keqing;YAO Zhiren;HUANG Yaping;ZHANG Jian;QIN Yanhua;YIN Zhiqi(Department of Traditional Chinese Pharmaceutic,School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 211198;Jiangsu Provincial Academy of Traditional Chinese Medicine,Nanjing 210028;China Tobacco Jiangsu Industrial Co.,Ltd.,Nanjing 210019,China)

机构地区：[1]中国药科大学中药学院中药制药系,南京211198 [2]江苏省中医药研究院转化医学实验室,南京210028 [3]江苏中烟工业有限责任公司,南京210019

出　　处：《中国药科大学学报》2023年第1期56-61,共6页Journal of China Pharmaceutical University

基　　金：国家自然科学基金资助项目(No.81872984);江苏高校“青蓝工程”资助项目;江苏中烟工业有限责任公司科技项目(No.H202204)。

摘　　要：对青钱柳[Cyclocarya paliurus(Batalin)Iljinskaja]叶的乙醇提取物正丁醇萃取部位进行化学成分研究。综合应用硅胶、MCI、ODS、Sephadex LH-20柱色谱、半制备高效液相色谱等多种色谱技术进行分离纯化,从中分离得到8个糖苷类化合物。根据理化性质及光谱数据分别鉴定为3-乙基-4-甲基戊酯-O-β-D-呋喃芹糖-(1→6)-β-D-吡喃葡萄糖苷(1)、胡桃苷E(2)、(4S)-α-松油醇-8-O-α-L-呋喃阿拉伯糖-(1→6)-β-D-吡喃葡萄糖苷(3)、(4S)-α-松油醇-8-O-β-D-呋喃芹糖-(1→6)-β-D-吡喃葡萄糖苷(4)、丁子香酚-O-β-D-呋喃芹糖-(1→6)-O-β-D-吡喃葡萄糖苷(5)、山柰酚-3-O-β-D-吡喃葡萄糖醛酸甲酯(6)、山柰酚-3-O-β-D-吡喃葡萄醛酸苷(7)、槲皮素-3-O-β-D-吡喃葡萄醛酸苷(8)。其中化合物1为新化合物,化合物2~6为首次从青钱柳属中分离得到。Chemical constituents of n-butanol part of ethanol extract from the leaves of Cyclocarya paliurus(Batalin)Iljinskaja were studied.Eight glycosides were separated and purified by silica gel,MCI,ODS,Sephadex LH-20 column chromatography and semi-preparative high-performance liquid chromatography.Based on the physicochemical properties and spectral data,these compounds were 3-ethyl-4-methyl-pentyl ester-O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside(1),juglanoside E(2),(4S)-α-terpineol-8-O-α-L-arabinofuranosyl-(1→6)-β-D-glucopyranoside(3),(4S)-α-terpineol-8-O-β-D-apiofuranosyl-(1→6)-β-D-glucopyranoside(4),eugenyl-O-β-Dapiofuranosyl-(1→6)-O-β-D-glucopyranoside(5),kaempferol-3-O-β-D-glucuronopyranosyl methylester(6),kaempferol-3-O-β-D-glucuronopyranoside(7),and quercetin-3-O-β-D-glucuronopyranoside(8).Among them,compound 1 was a new compound,and compounds 2-6 were isolated from the genus Cyclocarya for the first time.

关 键 词：青钱柳 化学成分 糖苷 分离鉴定 

分 类 号：R284[医药卫生—中药学]