人羊膜上皮干细胞治疗早产儿支气管肺发育不良的研究现状  

Current research status in treatment of preterm infants with bronchopulmonary dysplasia by human amniotic epithelial stem cells

作　　者：袁冰 颜凯 Bing Yuan;Kai Yan(Department of Pediatrics,the First Affiliated Hospital of Nanchang University,Nanchang 330006,Jiangxi Province,China)

机构地区：[1]南昌大学第一附属医院儿科,南昌330006

出　　处：《中华妇幼临床医学杂志（电子版）》2022年第6期640-644,共5页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

基　　金：江西省卫生健康委科技计划(SKJP220212361)。

摘　　要：随着围生医学的进步,早产儿尤其是极早产儿和超早产儿生存率大大提高,但是随之而来的支气管肺发育不良(BPD)越来越成为临床迫切需要解决的一大难题。干细胞可用于早产儿BPD治疗,可通过减少炎症、降低肺纤维化及抗氧化应激损伤等修复受损组织,特别是人羊膜上皮干细胞(hAESC),具有自我更新、多向分化潜能、无致瘤性、低免疫原性、无医学伦理纠纷、强大旁分泌作用及免疫调节作用等显著优势,可改善患儿心、肺功能,而成为目前早产儿BPD治疗的研究热点。笔者拟就hAESC治疗早产儿BPD的作用机制及其优势与挑战等的最新研究现状进行阐述。With advancement of perinatal medicine,the survival rate of preterm infants,especially very preterm infants and extremely preterm infants have been increased greatly,but the consequent bronchopulmonary dysplasia(BPD)has become an increasingly urgent clinical problems.In recent years,many experimental and clinical studies have found that stem cells can be used in treatment of preterm infants with BPD to repair damaged tissues by reducing their inflammation and pulmonary fibrosis,anti-oxidative stress damage,human amniotic epithelial stem cell(hAESC)especially have significant advantages such as self-renewing,multi-directional differentiation potential,without tumorigenicity,low immunogenicity,without medical ethics disputes,strong paracrine property and immunoloregulation function,and have the effect of improving human cardiopulmonary function,which has become a research hotspot in the treatment of preterm infant with BPD.The author intends to elaborate on current research status of mechanism of action,advantages and challenges of hAESC for treatment of preterm infant with BPD.

关 键 词：支气管肺发育不良 人羊膜上皮干细胞 成体干细胞 致瘤性 免疫原性 安全性 婴儿 早产 

分 类 号：R722.6[医药卫生—儿科]