蒲公英提取物提取工艺的优化及其阴道栓的制备工艺研究  

Optimization of Extraction Process of Dandelion Extract and Preparation of Vaginal Suppository

作　　者：余瑞龙 吴杨春 李光军 史甜甜 覃鑫蕊 张冕[1] YU Rui-long;WU Yang-chun;LI Guang-jun;SHI Tian-tian;QIN Xin-rui;ZHANG Mian(College of Chemical Engineering and Pharmacy,Jingchu University of Technology,Jingmen 448000,China)

机构地区：[1]荆楚理工学院化工与药学院,湖北荆门448000

出　　处：《安徽化工》2023年第1期83-88,共6页Anhui Chemical Industry

基　　金：荆楚理工学院大学生创新创业计划训练项目(KC2021030)。

摘　　要：以蒲公英为研究对象,采用超声波提取法同时提取蒲公英中黄酮类化合物及酚酸类化合物,将总酚酸和总黄酮的得率进行加权处理后作为指标,通过正交试验优化提取工艺。筛选适宜的基质,将提取物采用热熔法制备成蒲公英阴道栓,采用正交试验对栓剂的处方进行优化,对外观、硬度及融变时限进行综合评分后作为指标。优化后的提取工艺简便可行,制得的蒲公英阴道栓外观光滑、色泽均一、硬度适宜,融变时限符合药典的要求。Taking Dandelion as the research object,the phenolic acids and flavonoids in Dandelionwere extracted by ultrasonicextraction method.The comprehensive value of the weighted total phenolic acid yield and total flavonoids yield was taken as the index.The extraction process was optimized by orthogonal test.The Dandelionvaginal suppository was further prepared by hot-melt method.The comprehensive evaluation of appearance,hardness and melting time limit was taken as the index.The prescription of suppository was also optimized by orthogonal test.The extraction process is simple and feasible.The prepared Dandelionvaginal suppositories have smooth appearance,uniform color,appropriate hardness,and the melting time limit meet the requirements of the Pharmacopoeia.

关 键 词：蒲公英 超声波提取 芦丁 咖啡酸 正交试验 阴道栓 

分 类 号：R283.6[医药卫生—中药学]