吲哚-吡啶化合物的制备及其在检测二氧化硫衍生物和线粒体膜电位中的应用  

Preparation of Indole-pyridine Compounds and Their Applications in the Detection of Sulfur Dioxide Derivatives and Mitochondrial Membrane Potential

作　　者：杨锐 徐敬阳 赵宇昂 朱涛 陈宇琪 孙梦妮 陈正洋 韩志达 魏蒙蒙 YANG Rui;XU Jingyang;ZHAO Yuang;ZHU Tao;CHEN Yuqi;SUN Mengni;CHEN Zhengyang;HAN Zhida;WEI Mengmeng(School of Electronic Information and Engineering,Changshu Institute of Technology,Changshu 215500,China)

机构地区：[1]常熟理工学院电子信息工程学院,江苏常熟215500

出　　处：《常熟理工学院学报》2023年第2期8-12,共5页Journal of Changshu Institute of Technology

基　　金：国家自然科学基金青年科学基金项目“有机手性小分子共晶中分子排布调控光子-自旋耦合的研究”(12204067);江苏省自然科学基金青年基金项目“有机手性小分子共晶中调控光子-自旋耦合的研究”(BK20220689);江苏省教育厅自然科学研究面上项目“有机手性给受体共晶Bper-FTCNQ中调控光子-自旋耦合的研究”(22KJB140006);常熟理工学院科研启动基金项目(KYZ2021055Q,KYZ2021056Q)。

摘　　要：二氧化硫和细胞膜电位都参与细胞的重要生命活动,因此,观测细胞内的线粒体膜电位和二氧化硫衍生物对研究与之相关的生命活动至关重要.目前,可观测线粒体膜电位和二氧化硫衍生物的荧光探针往往需要洗涤过程,这会对细胞产生损伤.为此,本文设计合成了可以观测细胞线粒体膜电位和细胞内二氧化硫衍生物的多用途荧光探针,并用此探针观测了细胞线粒体膜电位和细胞内二氧化硫衍生物的变化.此外,该探针的生物相容性较好,可以为与细胞线粒体膜电位和细胞内二氧化硫衍生物相关的疾病诊断提供重要工具,并促进相关学科的发展.Both sulfur dioxide and cell membrane potential are involved in vital life activities of cells.Therefore,the observation of mitochondrial membrane potential and sulfur dioxide derivatives in cells is critical to the study of the life activities related to them.In view of the fact that fluorescent probes that are currently in use to observe mitochondrial membrane potential and sulfur dioxide derivatives may cause cell damage in the oftentimes requires washing procedure,we designed and synthesized a multipurpose fluorescent probe that can observe both mitochondrial membrane potential and intracellular sulfur dioxide derivatives and the changes of the latter.In addition,the probe affords a relatively advanced biocompatibility:it can function as a critical tool for the diagnosis of diseases related to mitochondrial membrane potential and intracellular sulfur dioxide derivatives,promising high potential to promote the development of related disciplines.

关 键 词：线粒体膜电位 二氧化硫衍生物 荧光探针 细胞成像 

分 类 号：O62[理学—有机化学]