急性缺血性脑卒中桥接血管再通后早期神经功能恶化分析  

Analysis of early neurological deterioration after bridging therapy for acute ischemic stroke after vascular occlusion and recanalization

作　　者：吴晓翠 施雪英[1] 严银天 方平[1] 吴鹏超[1] 方国真 王雷[1] WU Xiao-cui;SHI Xue-ying;YAN Yin-tian(Anqing Medical Center of Anhui Medical University,Anqing 246000,Anhui)

机构地区：[1]安徽医科大学安庆医学中心,安徽安庆246000

出　　处：《安徽医专学报》2023年第1期31-34,共4页Journal of Anhui Medical College

基　　金：安庆市科技局科研基金项目(编号:2021Z2008)。

摘　　要：目的:探讨急性缺血性脑卒中(AIS)患者桥接治疗(BT)血管再通后早期神经功能恶化的危险因素,为临床干预提供思路。方法:回顾分析70例接受BT血管再通后的AIS患者资料,根据神经功能恶化发生情况分为恶化组(END)与非恶化组(NEND),收集临床资料,分析相关危险因素。结果:END组心房颤动、低密度脂蛋白(LDL)、发病至股动脉穿刺时间(OPT)≥5 h、侧支循环分级≤2级、Alberta早期CT评分(ASPECTS)评分与NEND组相比,差异有统计学意义(P<0.05);将这5个因素纳入回归分析,得出OPT≥5 h、侧支循环分级≤2级、心房颤动是BT后发生END的独立危险因素。结论:心房颤动、LDL、OPT≥5 h、侧支循环分级≤2级、ASPECTS评分与END相关;心房颤动、OPT≥5 h、侧支循环分级≤2级与END呈独立相关。Objective:To analyze the related risk factors for early neurological deterioration in patients with acute ischemic stroke(AIS)after bridging therapy(BT)vascular occlusion and recanalization,and to provide means for clinical intervention.Methods:70 patients with AIS after undergoing BT revascularization were retrospectively analyzed and divided into the deterioration group(early neurological deterioration,END)and the non-early neurological deterioration(NEND)group according to the occurrence of neurological deterioration to collect clinical data and analyze related risk factors.Results:Atrial fibrillation,low density lipoprotein(LDL),time from onset to femoral artery puncture(OPT)≥5 h,collateral circulation grade≤2,and Alberta early CT score(ASPECTS)score were significantly different between the two groups(P<0.05);5 factors in the above analysis were included in logistic regression analysis,showing that OPT≥5 h,collateral circulation grade≤2,Atrial fibrillation was an independent risk factor for END after BT.Conclusion:AF,LDL,OPT≥5 h,collateral circulation grade≤2,and ASPECTS score were associated with END;AF,OPT≥5 h,and collateral circulation grade≤2 were independently associated with END.

关 键 词：急性缺血性脑卒中 桥接治疗 早期神经功能恶化 危险因素 

分 类 号：R743.3[医药卫生—神经病学与精神病学]