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作 者:刘丹丹[1] 关恒民 陈劲[1] LIU Dan-dan;GUAN Heng-min;CHEN Jin(The Second People's Hospital of Hefei Geriatrics,Hefei 230011,Anhui)
机构地区:[1]合肥市第二人民医院老年科,安徽合肥230011
出 处:《安徽医专学报》2023年第1期35-37,共3页Journal of Anhui Medical College
基 金:安徽医科大学校内重点研究基金项目(编号:2019xkj191)。
摘 要:目的:探讨老年性高血压患者血浆同型半胱氨酸Hcy、颈动脉斑块形成、血脂与血压的变异之间的相关性。方法:随机选取就诊于医院老年科的高血压病患者108例,0.9 mm≤IMT<1.3 mm为IMT硬化组31例(Y组);IMT≥1.3mm颈动脉斑块形成为斑块组77例(B组);一侧颈内动脉斑块形成或颈总动脉斑块形成为B1组35例;颈总动脉和左右颈内动脉斑块形成为B2组42例。所有入选研究对象均实施24 h动态血压监测,分析研究者颈动脉斑块形成与血压的变异性指标的关系。结果:患者基线资料比较中,年龄、性别、抽烟史、长期口服使用高血压病药物史、合并糖尿病史、他汀类服药史、空腹血糖、肌酐、尿酸、TG、TC、LDL-C、HDL-C、CRP、肌酸激酶差异均无统计学意义(P>0.05),具有可比性;患者年龄、长期服用抗血小板药物、饮酒史、合并冠心病史、Hcy,差异均有统计学意义(P<0.05);三组间dDBP-CV、nSBP比较,差异有统计学意义(P<0.05);dDBP-CV与硬化组比较,斑块B1、B2组均明显升高,差异有统计学意义(P<0.05);nSBP与硬化组比较,斑块B2组明显升高,差异有统计学意义(P<0.05)。结论:对于老年高血压患者颈动脉硬化及斑块形成,dDBP-CV增加、nSBP升高是血管病变的促进因素。Objective:To study the relationship between plasma homocysteine Hcy,carotid plaque formation,blood lipids and blood pressure variability in elderly hypertensive patients.Methods:108 patients with hypertension who visited the geriatric department of Hospital were randomly selected.31 patients(group Y)in IMT sclerotherapy group were 0.9 mm≤IMT<1.3 mm;Carotid plaque with IMT≥1.3 mm was divided into plaque group(77 cases,group B);In group B1,35 patients had plaque formation in one internal carotid artery or common carotid artery;The common carotid artery and left and right internal carotid artery plaques were found in 42 patients in group B2.All patients underwent 24 hour ambulatory blood pressure monitoring.To analyze the relationship between carotid plaque formation and blood pressure variability.Results:Compared with the baseline data of patients,there were no statistically significant differences in gender,smoking history,long-term history of taking hypertension drugs,history of combined diabetes,history of taking statins,fasting blood glucose,creatinine,uric acid,TG,TC,LDL-C,HDL-C,CRP,creatine kinase,which were comparable(P>0.05);There were significant differences in age,long-term use of antiplatelet drugs,drinking history,history of coronary heart disease,Hcy(P<0.05);There were significant differences in dDBP-CV and nSBP among the three groups(P<0.05);Compared with sclerotic group,the levels of dDBP-CV in plaque B1 and B2 groups were significantly higher(P<0.05);Compared with sclerotic group,nSBP in plaque B2 group was significantly higher(P<0.05).Conclusion:Carotid arteriosclerosis and plaque formation in elderly patients with hypertension are related to age,long-term use of antiplatelet drugs,drinking history,history of coronary heart disease,and increase of Hcy.The increase of dDBPCV and nSBP are the promoting factors of vascular disease.
分 类 号:R544.1[医药卫生—心血管疾病]
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