姜黄素治疗肾间质纤维化分子机制研究进展  

Research progress on molecular mechanism of curcumin in treatment of renal interstitial fibrosis

作　　者：陈欠欠 朱凤阁 陈香美 CHEN Qian-qian;ZHU Feng-ge;CHEN Xiang-mei(School of Traditional Chinese Medicine,Guangdong Pharmaceutical University,Guangzhou 510006,China;Nephrology Institute of the Chinese People's Liberation Army,State Key Laboratory of Kidney Diseases,National Clinical Research Center for Kidney Diseases,Beijing Key Laboratory of Kidney Disease Research,Department of Nephrology,Chinese PLA General Hospital,Beijing 100853,China)

机构地区：[1]广东药科大学中药学院,广东广州510006 [2]解放军总医院肾脏病科,全军肾脏病研究所,肾脏疾病国家重点实验室,国家慢性肾病临床医学研究中心,肾脏疾病研究北京市重点实验室,北京100853

出　　处：《中草药》2023年第3期966-975,共10页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(32141005);北京市科技计划项目(D18110700010000)。

摘　　要：姜黄素是一种脂溶性多酚类化合物,目前有多项姜黄素治疗慢性肾脏病的临床试验。检索了姜黄素治疗肾脏纤维化的相关研究,从抑制炎症反应、抗氧化应激和抑制肾小管上皮细胞-间充质转变等分子机制方面归纳总结了姜黄素治疗肾间质纤维化的重要信号通路,以期为其进一步研究和开发提供借鉴。Curcumin is a fat-soluble polyphenolic compound. At present, there are several clinical trials of curcumin in treatment of chronic kidney disease. Relevant researches on curcumin in treatment of renal fibrosis were searched, the important signaling pathways of curcumin in treatment of renal interstitial fibrosis were summarized from the molecular mechanisms of inhibiting inflammatory response, anti-oxidative stress and inhibiting renal tubular epithelial-mesenchymal transition in this paper, in order to provide reference for its further research and development.

关 键 词：姜黄素 慢性肾脏病 肾间质纤维化 抗炎 氧化应激 上皮细胞-间充质转变 

分 类 号：R285.5[医药卫生—中药学]