当归四逆汤化学成分、药理作用和临床应用的研究进展及质量标志物(Q-Marker)的预测分析  

Research progress on chemical constituents,pharmacological effects and clinical applications of Danggui Sini Decoction and predictive analysis of its quality marker(Q-Marker)

作　　者：王明慧 马飞[2] 田崇娅 丁语晨 徐园园 王加锋 魏永利[2] 辛义周[2] WANG Ming-hui;MA Fei;TIAN Chong-ya;DING Yu-chen;XU Yuan-yuan;WANG Jia-feng;WEI Yong-li;XIN Yi-zhou(College of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Grade Three Laboratory of Traditional Chinese Medicine Preparation of State Administration of Traditional Chinese Medicine,Affiliated Hospital of Shandong University of Traditional Chinese Medicine,Jinan 250011,China;College of Pharmacy,Jining Medical University,Rizhao 276826,China;College of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Jinan 250355,China)

机构地区：[1]山东中医药大学药学院,山东济南250355 [2]山东中医药大学附属医院、国家中医药管理局中药制剂三级实验室,山东济南250011 [3]济宁医学院药学院,山东日照276826 [4]山东中医药大学中医学院,山东济南250355

出　　处：《中草药》2023年第3期991-1001,共11页Chinese Traditional and Herbal Drugs

基　　金：国家中医药管理局公益性行业专项“中药炮制技术传承基地”建设项目;山东省中医药科技发展计划项目(2019-0074);山东省研究生教育质量提升计划项目(SDYKC21047);齐鲁医派中医学术流派传承项目(齐鲁道地药材炮制存性特色技术)。

摘　　要：当归四逆汤(Danggui Sini Decoction,DSD)是治疗血虚寒厥证的代表方剂,具有温经散寒、养血通脉等功效,临床多用于治疗冠心病、心绞痛、雷诺氏征、糖尿病周围神经病变、痛经、膝骨关节炎等疾病。在对DSD化学成分、药理作用和临床应用研究进展进行综述的基础上,依据中药质量标志物(quality marker,Q-Marker)“五原则”对其Q-Marker进行预测分析。结果提示阿魏酸、藁本内酯、肉桂酸、桂皮醛、芍药苷、芍药内酯苷、甘草苷、甘草酸和细辛脂素可作为DSD的Q-Marker,为DSD及其相关制剂的质量控制等后续研究提供参考。Danggui Sini Decoction(当归四逆汤,DSD)is a representative prescription in treatment of blood deficiency and cold syncope,which has the effects of warming meridians and dispelling cold,nourishing blood and promoting pulse.It is often used in clinical practice to treat coronary heart disease,angina pectoris,Raynaud’s phenomenon,diabetic peripheral neuropathy,dysmenorrhea,knee osteoarthritis,etc.Based on research progress on chemical constituents,pharmacological effects and clinical applications of DSD,its Q-marker was predicted and analyzed according to the“five principles”of traditional Chinese medicine quality marker(Q-Marker).The results suggested that ferulic acid,ligustilide,cinnamic acid,cinnamal dehyde,paeoniflorin,albiforin,liquirtin,glycyrrhizic acid and asarinin could be used as Q-Markers of DSD,which provide reference for the follow-up research on quality control of DSD and related preparations.

关 键 词：当归四逆汤 质量标志物 阿魏酸 藁本内酯 肉桂酸 桂皮醛 芍药苷 芍药内酯苷 甘草苷 甘草酸 细辛脂素 

分 类 号：R283.661[医药卫生—中药学]