黄芪甲苷抗肿瘤作用机制研究进展  

Research progress on antitumor mechanism of astragaloside Ⅳ

作　　者：孟丹丹 李宗新 贾瑞雪 包兴勋 王万涛 宋素花 MENG Dan-dan;LI Zong-xin;JIA Rui-xue;BAO Xing-xun;WANG Wan-tao;SONG Su-hua(School of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Second Department of Hematology,Jinan Hematology Hospital,Jinan 250014,China;School of Basic Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]山东中医药大学中医学院,山东济南250355 [2]济南血液病医院血液二科,山东济南250014 [3]上海中医药大学基础医学院,上海201203

出　　处：《中草药》2023年第3期1002-1009,共8页Chinese Traditional and Herbal Drugs

基　　金：山东省研究生教育优质课程建设项目(SDYKC20054);齐鲁医派中医学术流派传承项目(鲁卫函[2022]93号)。

摘　　要：黄芪甲苷是从黄芪Astragali Radix中提取得到的皂苷类化合物,是黄芪的主要有效成分之一,具有抗炎、抗氧化、免疫调节、调节代谢及抗肿瘤等药理作用,近年来在抗肿瘤领域备受关注。研究发现黄芪甲苷能抑制肿瘤细胞增殖,进一步抑制肺癌、结直肠癌、肝癌、宫颈癌、卵巢癌等癌症进展。其抗肿瘤作用机制主要有抑制肿瘤细胞增殖、促进肿瘤细胞凋亡、阻滞细胞周期进程、抑制肿瘤细胞侵袭等,此外还发现黄芪甲苷能在一定程度上增强抗肿瘤药物敏感性和提高机体免疫力。黄芪甲苷可通过多种途径发挥抗肿瘤作用,在抗肿瘤治疗领域有广阔的应用前景。对其抗肿瘤作用及机制进行综述,以期为临床的肿瘤治疗提供新的理论支持与借鉴。Astragalus Ⅳ is the saponin compound extracted from Huangqi(Astragali Radix), which is one of the main active ingredients from Astragali Radix. It has a wide range of pharmacological effects such as anti-inflammatory, anti-oxidant, immune regulation, metabolism regulation and antitumor, and has attracted much attention in the field of antitumor in recent years. It was found that astragaloside Ⅳ can inhibit the proliferation of tumor cells and further inhibit the progression of cancers such as lung cancer,colorectal cancer, liver cancer, cervical cancer, and ovarian cancer. The antitumor mechanism of astragaloside Ⅳ mainly includes inhibiting tumor cell proliferation, promoting tumor cell apoptosis, blocking cell cycle process, inhibiting tumor cell invasion, etc. In addition, it was also found that astragaloside Ⅳ can enhance the sensitivity of antitumor drugs and improve the body immunity to a certain extent. Astragaloside Ⅳ can exert antitumor effects through various ways, and has broad application prospects in the field of antitumor therapy. This paper reviews the antitumor effects and mechanisms of astragaloside Ⅳ, in order to provide new theoretical support and reference for clinical antitumor therapy.

关 键 词：黄芪 黄芪甲苷 肿瘤 抗肿瘤活性 作用机制 中医药 

分 类 号：R285[医药卫生—中药学]